testosterone propionate [Ligand Id: 7100] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1170 (NRB-03689, NSC-9166, Orchisterone, Testosteron 17-propionate, Testosterone 17.beta.-propionate, Testosterone propionate, Testosterone Propionate, Testosterone propionate ciii, Testosteroni propionas, Virormone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| GtoPdb | - | - | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 4487-90 [PMID:17574413] |
| ChEMBL | Displacement of [3H]DHT from human androgen receptor in MDA453 cells | B | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 4487-4490 [PMID:17574413] |
| ChEMBL | Displacement of [3H]mibolerone from human AR expressed in COS cells after 3.5 hrs by liquid scintillation counting analysis | B | 7.74 | pIC50 | 18 | nM | IC50 | Medchemcomm (2013) 4: 582-589 |
| Androgen receptor/Androgen Receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091] | ||||||||
| ChEMBL | Agonist activity at androgen receptor in mouse C2C12 cells by receptor transactivation assay | F | 8.55 | pEC50 | 2.8 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 4487-4490 [PMID:17574413] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | B | 5.72 | pIC50 | 1905.46 | nM | IC50 | J Med Chem (2005) 48: 5666-5674 [PMID:16134935] |
| CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093] | ||||||||
| ChEMBL | In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escherichia coli or P450c17-LNCaP cells as the enzyme source. | B | 7.25 | pIC50 | 56 | nM | IC50 | J Med Chem (2003) 46: 2345-2351 [PMID:12773039] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
