ChEMBL ligand: CHEMBL814 (Fluvoxamine, N06AB08)
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] DAT/Dopamine transporter in Rat [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Rat [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] There should be some charts here, you may need to enable JavaScript!
Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] There should be some charts here, you may need to enable JavaScript!
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)	B	8.84	pKi	1.46	nM	Ki	J Med Chem (2003) 46: 925-935 [PMID:12620070]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL	Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamine	F	4.35	pIC50	45000	nM	IC50	J Med Chem (1984) 27: 1508-1515 [PMID:6492080]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of hERG K channel	F	5.51	pIC50	3100	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL	Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrine	F	5.72	pIC50	1900	nM	IC50	J Med Chem (1984) 27: 1508-1515 [PMID:6492080]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
GtoPdb	-	-	8.66	pKd	2.2	nM	Kd	Eur J Pharmacol (1997) 340: 249-58 [PMID:9537821]
ChEMBL	Displacement of [3H]citalopram from human SERT in HEK293 cells by Topcount scintillation analysis	B	6.34	pKi	458	nM	Ki	Eur J Med Chem (2021) 220: 113533-113533 [PMID:34049262]
ChEMBL	Inhibition constant against [3H]citalopram in murine kidney cells transfected with human dopamine transporter	B	8.51	pKi	3.08	nM	Ki	J Med Chem (2000) 43: 639-648 [PMID:10691690]
ChEMBL	Inhibition of SERT (unknown origin)	B	8.42	pIC50	3.8	nM	IC50	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
GtoPdb	Inhibition of [3]5-HT uptake into rat astrocyte cultures.	-	8.19	pKi	6.5	nM	Ki	Neurochem Int (2001) 39: 39-49 [PMID:11311448]
ChEMBL	Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HT	F	6.27	pIC50	540	nM	IC50	J Med Chem (1984) 27: 1508-1515 [PMID:6492080]
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7]
ChEMBL	Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat brain membranes in presence of (+)-pentazocine by scintillation counting method	B	5.07	pKi	8439	nM	Ki	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
GtoPdb	Binding affinity.	-	7.44	pKi	36	nM	Ki	ACS Med Chem Lett (2012) 3: 1054-1058 [PMID:23641311]; J Clin Psychiatry (2008) 69: 1673-4 [PMID:19200426]
ChEMBL	Binding affinity to sigma 1 receptor	B	7.44	pKi	36	nM	Ki	ACS Med Chem Lett (2012) 3: 1054-1058 [PMID:23641311]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL	Displacement of [3H]-(+)pentazocine from rat brain sigma 1-type opioid receptor	B	7.44	pKi	36	nM	Ki	J Med Chem (2012) 55: 5350-5360 [PMID:22515405]
ChEMBL	Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting method	B	7.44	pKi	36	nM	Ki	J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL	Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA	F	4.4	pIC50	39400	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
ChEMBL	Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes	F	5.31	pIC50	4900	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
ChEMBL	Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes	F	5.31	pIC50	4900	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]