levamisole [Ligand Id: 7210] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1454 (Levamisole, TCMDC-125847, Tetramisole, (s)-) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alkaline phosphatase, tissue-nonspecific isozyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5979] [UniProtKB: P05186] | ||||||||
| ChEMBL | Inhibition of TNSALP | B | 4.8 | pKi | 16000 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 222-225 [PMID:19038545] |
| ChEMBL | Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured after 20 mins by luminescence-based assay | B | 4.69 | pIC50 | 20210 | nM | IC50 | Eur J Med Chem (2018) 156: 461-478 [PMID:30015078] |
| ChEMBL | Inhibition of human TNAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by substrate addition and measured after 15 to 20 mins by spectrophotometric method | B | 4.69 | pIC50 | 20200 | nM | IC50 | Eur J Med Chem (2018) 159: 282-291 [PMID:30296687] |
| ChEMBL | Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by luminescence assay | B | 4.72 | pIC50 | 19200 | nM | IC50 | Eur J Med Chem (2018) 144: 116-127 [PMID:29268128] |
| ChEMBL | Inhibition of TNAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
| Alkaline phosphatase, tissue-nonspecific isozyme in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2406894] [UniProtKB: P09487] | ||||||||
| ChEMBL | Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method | B | 5.74 | pKi | 1810 | nM | Ki | Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133] |
| ChEMBL | Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method | B | 4.72 | pIC50 | 19210 | nM | IC50 | Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133] |
| ChEMBL | Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectrophotometric method | B | 4.72 | pIC50 | 19210 | nM | IC50 | Eur J Med Chem (2017) 126: 408-420 [PMID:27907877] |
| Intestinal alkaline phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5573] [UniProtKB: P09923] | ||||||||
| ChEMBL | Inhibition of human IAP using CDP-star as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins by spectrophotometric method | B | 4.69 | pIC50 | 20210 | nM | IC50 | Eur J Med Chem (2017) 131: 29-47 [PMID:28288318] |
| ChEMBL | Inhibition of IAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
| Phospholipase A-2-activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263] | ||||||||
| ChEMBL | Inhibition of PLAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
