mercaptopurine [Ligand Id: 7226] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1425 (Mercaptopurine, Mercaptopurine anhydrous, Purinethol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 4.79 | pIC50 | 16242 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 | F | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| ChEMBL | Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7 | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| Purine nucleoside phosphorylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169594] [UniProtKB: P9WP01] | ||||||||
| ChEMBL | Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis | B | 4.1 | pKd | 79432.82 | nM | Kd | Bioorg Med Chem (2010) 18: 4769-4774 [PMID:20570524] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
