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ChEMBL ligand: CHEMBL625 (E233, Equizole, Lombristop, Mintezol, Minzolum, MK-360, Nemapan, NSC-525040, NSC-90507, Omnizole, Pitrizet, Thiabendazole, Thiabenzole, Tiabendazole) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 6.1 | pIC50 | 800 | nM | IC50 | DrugMatrix in vitro pharmacology data |
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
ChEMBL | Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry | B | 4.22 | pKd | 60000 | nM | Kd | J Med Chem (2007) 50: 6607-6617 [PMID:18038971] |
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTP | B | 4.84 | pIC50 | 14600 | nM | IC50 | J Med Chem (2002) 45: 5410-5413 [PMID:12431069] |
Methionine aminopeptidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18] | ||||||||
ChEMBL | Inhibition of Co2+ loaded MetAP expressed in Escherichia coli | B | 6.33 | pIC50 | 472 | nM | IC50 | J Med Chem (2006) 49: 511-522 [PMID:16420038] |
Methionyl aminopeptidase 1/Methionine aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2474] [GtoPdb: 1572] [UniProtKB: P53582] | ||||||||
ChEMBL | Inhibition of human MetAP1 | B | 4.32 | pIC50 | 47800 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4038-4044 [PMID:20621724] |
ChEMBL | Inhibition of human methionine aminopeptidase 1 in presence of Mn2+ | B | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2013) 56: 3996-4016 [PMID:23634668] |
ChEMBL | Inhibition of human methionine aminopeptidase 1 in presence of Co2+ | B | 5.47 | pEC50 | 3400 | nM | EC50 | J Med Chem (2013) 56: 3996-4016 [PMID:23634668] |
Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579] | ||||||||
ChEMBL | Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells | B | 4.35 | pIC50 | 44700 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4038-4044 [PMID:20621724] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]