tolazoline [Ligand Id: 7310] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL770 (NSC-35110, Priscoline, Tolazine, Tolazoline) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1998) 41: 2243-2251 [PMID:9632357] |
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1B receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4697-4699 [PMID:15324890] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1998) 41: 2243-2251 [PMID:9632357] |
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1D receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4697-4699 [PMID:15324890] |
| TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] | ||||||||
| ChEMBL | Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by beta counting analysis | B | 5.79 | pKi | 1640 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 5244-5248 [PMID:22795332] |
| α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 6.7 | pKi | 199 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
| α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 5.5 | pKi | 3162 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
| α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
| GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 5.43 | pKi | 3715 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
