flutemetamol [Ligand Id: 7342] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2042122 ((18F)AH110690, [18F]AH110690, (18f)flutemetamol, [18F]-Flutemetamol F18, Flutemetamol (18f), Flutemetamol f 18, Flutemetamol f-18, Flutemetamol F18, Flutemetamol ((sup18)f), Vizamyl) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hr | B | 9.13 | pKi | 0.74 | nM | Ki | J Med Chem (2011) 54: 8085-8098 [PMID:22011144] |
| ChEMBL | Binding affinity to human amyloid beta plaque | B | 9.15 | pKi | 0.7 | nM | Ki | ACS Med Chem Lett (2012) 3: 265-267 [PMID:24936237] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
