Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1259059 (GS-7977, GS7977, PSI-7977, Psi-7977, gs-7977, Sofosbuvir, Sovaldi) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Cereblon isoform 4 in Magnetospirillum gryphiswaldense (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763007] [UniProtKB: A4TVL0] | ||||||||
ChEMBL | Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assay | B | 4.57 | pKi | 27000 | nM | Ki | ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967] |
ChEMBL | Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform by FRET assay | B | 4.66 | pKi | 22000 | nM | Ki | ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967] |
Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8] | ||||||||
ChEMBL | Inhibition of NS5B S282T mutant in HCV genotype 1b replicon expressed in human HuH7 cells after 72 hrs by bright Glo-luciferase reporter gene assay | B | 6.23 | pEC50 | 589 | nM | EC50 | J Med Chem (2017) 60: 6077-6088 [PMID:28650160] |
ChEMBL | Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay | B | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay | B | 6.64 | pEC50 | 230 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126986-126986 [PMID:32046903] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay | B | 6.81 | pEC50 | 155 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126986-126986 [PMID:32046903] |
ChEMBL | Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase | B | 6.99 | pEC50 | 102 | nM | EC50 | Medchemcomm (2019) 10: 991-1006 [PMID:31303998] |
ChEMBL | Inhibition of Hepatitis C virus genotype 1b NS5B RNA-dependent-RNA polymerase assessed as reduction in viral replication after 72 hrs by indirect immunofluorescence assay | B | 7.19 | pEC50 | 64.26 | nM | EC50 | Bioorg Med Chem (2018) 26: 2621-2631 [PMID:29681484] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysis | B | 7.19 | pEC50 | 64 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysis | B | 7.21 | pEC50 | 61 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysis | B | 7.24 | pEC50 | 58 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysis | B | 7.36 | pEC50 | 44 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
ChEMBL | Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysis | B | 7.37 | pEC50 | 43 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
ChEMBL | Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay | B | 7.47 | pEC50 | 34 | nM | EC50 | J Med Chem (2019) 62: 1859-1874 [PMID:30653317] |
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7] | ||||||||
ChEMBL | Inhibition of RNA-dependent RNA polymerase in Zika virus infected in African green monkey Vero cells assessed as antiviral activity by DAPI-staining based assay | B | 4.51 | pEC50 | 30900 | nM | EC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
ChEMBL | Inhibition of RNA-dependent RNA polymerase in Zika virus infected in human NPC assessed as antiviral activity by DAPI-staining based assay | B | 6.92 | pEC50 | 120 | nM | EC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]