ChEMBL ligand: CHEMBL86304 (Aurorix, GNF-PF-695, Manerix, Moclobemide, RO 11-1163/000, RO-111163000)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] Monoamine oxidase A in Bovine [ChEMBL: CHEMBL3254] [UniProtKB: P21398] Monoamine oxidase A in Rat [ChEMBL: CHEMBL3358] [UniProtKB: P21396] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] Monoamine oxidase B in Bovine [ChEMBL: CHEMBL2756] [UniProtKB: P56560] Monoamine oxidase B in Rat [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG	B	4.1	pIC50	79432.82	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Inhibition of recombinant human MAO-A using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate addition measured for 15 mins by amplex red assay	B	6.96	pKi	110	nM	Ki	ACS Med Chem Lett (2016) 7: 56-61 [PMID:26819666]
ChEMBL	Inhibition of recombinant human MAO-A assessed as reduction in H2O2 production preincubated for 30 mins followed by p-tyramine substrate addition measured after 30 mins by amplex red reagent based fluorescence assay	B	6.99	pKi	102	nM	Ki	Medchemcomm (2018) 9: 1164-1171 [PMID:30109004]
ChEMBL	Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Amplex red reagent based fluorescence analysis	B	7	pKi	100	nM	Ki	J Med Chem (2021) 64: 1989-2009 [PMID:33533632]
ChEMBL	Inhibition of human MAOA expressed in baculovirus-infected BTI insect cells assessed as H2O2 production by resorufin dye based fluorimetric method	B	7.85	pKi	14	nM	Ki	Bioorg Med Chem Lett (2014) 24: 3278-3284 [PMID:24986657]
GtoPdb	-	-	8.3	pKi	5	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4296-300 [PMID:21680183]
ChEMBL	Inhibition of human MAO-A expressed in BTI insect cells using p-tyramine as substrate after 60 mins	B	8.3	pKi	5	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4296-4300 [PMID:21680183]
ChEMBL	Competitive reversible inhibition of human recombinant MAO-A expressed in baculovirus infected BT1 insect cells using p-tyramine as substrate assessed as H2O2 production after 15 mins by fluorimetric analysis	B	8.3	pKi	5	nM	Ki	Eur J Med Chem (2013) 69: 762-767 [PMID:24099995]
ChEMBL	Inhibition of human MAO-A using tyramine hydrochloride as substrate after 30 mins by Amplex Red reagent based horseradish peroxidase enzyme-coupled fluorescence assay	B	5.22	pIC50	6061	nM	IC50	Eur J Med Chem (2018) 144: 68-81 [PMID:29248751]
ChEMBL	Inhibition of human recombinant MAO-A using tyramine as substrate preincubated with enzyme for 30 mins followed by incubation with substrate for 30 mins by Amplex Red reagent based fluorometric method	B	5.33	pIC50	4664	nM	IC50	RSC Med Chem (2020) 11: 1063-1074 [PMID:33479699]
ChEMBL	Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI cells using p-tyramine as substrate after 15 mins by Amplex Red-based fluorescence assay	B	5.44	pIC50	3613.8	nM	IC50	Eur J Med Chem (2016) 108: 542-552 [PMID:26717204]
ChEMBL	Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 production	B	6.44	pIC50	361.38	nM	IC50	Bioorg Med Chem Lett (2015) 25: 642-648 [PMID:25532905]
Monoamine oxidase A in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3254] [UniProtKB: P21398]
ChEMBL	Inhibitory activity against monoamine oxidase A in isolated bovine brain mitochondria	B	4.94	pKi	11500	nM	Ki	J Med Chem (2003) 46: 917-920 [PMID:12620068]
ChEMBL	Inhibition of bovine brain mitochondria MAOA by fluorometric assay	B	4.94	pKi	11500	nM	Ki	J Med Chem (2007) 50: 922-931 [PMID:17256833]
ChEMBL	Inhibition of bovine brain mitochondrial MAO-A by fluorometric assay	B	4.94	pKi	11500	nM	Ki	Bioorg Med Chem (2008) 16: 9729-9740 [PMID:18951803]
ChEMBL	Inhibition of bovine brain MAOA using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorometric assay	B	4.94	pKi	11500	nM	Ki	J Med Chem (2012) 55: 10424-10436 [PMID:23153282]
ChEMBL	Inhibition of MAO-A in bovine brain mitochondria using serotonin as substrate preincubated for 30 mins measured after 30 mins by spectrofluorimetric analysis	B	4.88	pIC50	13100	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5281-5285 [PMID:26428872]
ChEMBL	Inhibition of MAO-A in bovine brain mitochondria by fluorimetric method	B	4.94	pIC50	11481.54	nM	IC50	J Med Chem (2007) 50: 425-428 [PMID:17266193]
ChEMBL	Inhibition of bovine mitochondrial MAOA	B	4.94	pIC50	11481.54	nM	IC50	Eur J Med Chem (2008) 43: 2262-2267 [PMID:18281126]
ChEMBL	Inhibition of bovine brain MAO-A preincubated for 60 mins before substrate addition by fluorimetric method	B	4.96	pIC50	11000	nM	IC50	Eur J Med Chem (2015) 93: 308-320 [PMID:25707011]
Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396]
ChEMBL	Displacement of [3H]-Ro 41-1049 from MAO-A receptor in rat cerebral cortex	B	4.93	pKi	11748.98	nM	Ki	J Med Chem (2012) 55: 3242-3249 [PMID:22385498]
ChEMBL	Displacement of [3H]Ro 41-1049 from MAO-A in rat cerebral cortex by competition binding assay	B	4.94	pKi	11500	nM	Ki	J Med Chem (2012) 55: 9735-9750 [PMID:23043306]
ChEMBL	Inhibitory concentration for rat Monoamine oxidase A	B	4.94	pKi	11500	nM	Ki	J Med Chem (2005) 48: 4220-4223 [PMID:15974574]
ChEMBL	Inhibition of MAO-A in rat liver homogenate after 60 mins by Lineweaver-Burke plot	B	5.26	pKi	5530	nM	Ki	Bioorg Med Chem (2009) 17: 675-689 [PMID:19091581]
ChEMBL	Competitive inhibition of MAOA in rat liver homogenate by spectrophotometrically	B	8.26	pKi	5.53	nM	Ki	Bioorg Med Chem (2009) 17: 6761-6772 [PMID:19682910]
ChEMBL	Competitive inhibition of MAOA in rat liver homogenate after 60 mins by Lineweaver-Burke plot analysis	B	8.26	pKi	5.53	nM	Kic	Bioorg Med Chem (2010) 18: 1875-1881 [PMID:20149663]
ChEMBL	Inhibition of MAO-A in rat liver homogenate by spectrophotometry-based Holt method	B	8.3	pKi	5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 132-136 [PMID:19945874]
ChEMBL	Inhibition of MAOA in Sprague-Dawley rat liver mitochondria using p-tyramine as substrate measured for 45 mins in presence of MAOB inhibitor selegiline by continuous fluorescence-based method	B	4.97	pIC50	10700	nM	IC50	Eur J Med Chem (2017) 127: 470-492 [PMID:28107736]
ChEMBL	Inhibition of MAO-A in Sprague-Dawley rat brain mitochondrial suspension using kynuramine as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by spectrophotometry	B	5	pIC50	10000	nM	IC50	J Med Chem (2013) 56: 2651-2664 [PMID:23437843]
ChEMBL	Inhibition of MAOA in Sprague-Dawley rat brain mitochondria using kynuramine substrate by fluorimetry	B	5.17	pIC50	6800	nM	IC50	Bioorg Med Chem (2010) 18: 1659-1664 [PMID:20117937]
ChEMBL	Inhibition of rat MAOA using 5-hydroxytryptamine as substrate pretreated for 1200 secs followed by substrate addition and measured after 3600 secs	B	5.2	pIC50	6300	nM	IC50	Bioorg Med Chem (2018) 26: 4863-4870 [PMID:30143367]
ChEMBL	Competitive inhibition of MAOA in rat liver homogenate by spectrophotometrically	B	5.24	pIC50	5700	nM	IC50	Bioorg Med Chem (2009) 17: 6761-6772 [PMID:19682910]
ChEMBL	Inhibition of MAO-A in rat liver homogenate after 60 mins by residual activity plot	B	5.41	pIC50	3900	nM	IC50	Bioorg Med Chem (2009) 17: 675-689 [PMID:19091581]
ChEMBL	Inhibition of MAOA in rat liver homogenates preincubated for 60 mins	B	5.41	pIC50	3900	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6362-6368 [PMID:18980841]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL	Inhibitory concentration for human Monoamine oxidase B	B	4	pKi	100000	nM	Ki	J Med Chem (2005) 48: 4220-4223 [PMID:15974574]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Amplex red reagent based fluorescence analysis	B	5.12	pKi	7660	nM	Ki	J Med Chem (2021) 64: 1989-2009 [PMID:33533632]
ChEMBL	Inhibition of recombinant human MAO-B assessed as reduction in H2O2 production preincubated for 30 mins followed by p-tyramine substrate addition measured after 30 mins by amplex red reagent based fluorescence assay	B	5.37	pKi	4220	nM	Ki	Medchemcomm (2018) 9: 1164-1171 [PMID:30109004]
ChEMBL	Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate addition measured for 15 mins by amplex red assay	B	5.65	pKi	2240	nM	Ki	ACS Med Chem Lett (2016) 7: 56-61 [PMID:26819666]
ChEMBL	Inhibition of human MAOB expressed in baculovirus-infected BTI insect cells assessed as H2O2 production by resorufin dye based fluorimetric method	B	5.87	pKi	1340	nM	Ki	Bioorg Med Chem Lett (2014) 24: 3278-3284 [PMID:24986657]
ChEMBL	Competitive reversible inhibition of human recombinant MAO-B expressed in baculovirus infected BT1 insect cells using p-tyramine as substrate assessed as H2O2 production after 15 mins by fluorimetric analysis	B	5.97	pKi	1080	nM	Ki	Eur J Med Chem (2013) 69: 762-767 [PMID:24099995]
ChEMBL	Inhibition of human MAO-B expressed in BTI insect cells using p-tyramine as substrate after 60 mins	B	5.97	pKi	1080	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4296-4300 [PMID:21680183]
GtoPdb	-	-	5.97	pKi	1080	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4296-300 [PMID:21680183]
ChEMBL	Inhibition of human MAO-B using p-tyramine as substrate by Amplex Red reagent based fluorescence analysis	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2020) 190: 112090-112090 [PMID:32018096]
ChEMBL	Inhibition of human recombinant MAO-B using tyramine as substrate by fluorescence assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2022) 65: 4727-4751 [PMID:35245051]
Monoamine oxidase B in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2756] [UniProtKB: P56560]
ChEMBL	Inhibitory activity against monoamine oxidase B in isolated bovine brain mitochondria	B	4	pKi	>100000	nM	Ki	J Med Chem (2003) 46: 917-920 [PMID:12620068]
ChEMBL	Inhibition of bovine brain mitochondria MAOB by fluorometric assay	B	4	pKi	>100000	nM	Ki	J Med Chem (2007) 50: 922-931 [PMID:17256833]
ChEMBL	Inhibition of bovine brain mitochondrial MAO-B by fluorometric assay	B	4	pKi	>100000	nM	Ki	Bioorg Med Chem (2008) 16: 9729-9740 [PMID:18951803]
ChEMBL	Inhibition of bovine brain MAOB using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorometric assay	B	4	pKi	>100000	nM	Ki	J Med Chem (2012) 55: 10424-10436 [PMID:23153282]
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643]
ChEMBL	Displacement of [3H]-Ro 16-6491 from MAO-B receptor in rat cerebral cortex	B	4	pKi	>100000	nM	Ki	J Med Chem (2012) 55: 3242-3249 [PMID:22385498]
ChEMBL	Inhibition of MAO-B in rat liver homogenate after 60 mins by Lineweaver-Burke plot	B	4.99	pKi	10210	nM	Ki	Bioorg Med Chem (2009) 17: 675-689 [PMID:19091581]
ChEMBL	Competitive inhibition of MAOB in rat liver homogenate by spectrophotometrically	B	5.97	pKi	1080	nM	Ki	Bioorg Med Chem (2009) 17: 6761-6772 [PMID:19682910]
ChEMBL	Inhibition of MAO-B in rat liver homogenate by spectrophotometry-based Holt method	B	5.97	pKi	1080	nM	Ki	Bioorg Med Chem Lett (2010) 20: 132-136 [PMID:19945874]
ChEMBL	Competitive inhibition of MAOB in rat liver homogenate after 60 mins by Lineweaver-Burke plot analysis	B	5.97	pKi	1080	nM	Kic	Bioorg Med Chem (2010) 18: 1875-1881 [PMID:20149663]
ChEMBL	Inhibition of MAOB in Sprague-Dawley rat brain mitochondria using kynuramine substrate by fluorimetry	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2010) 18: 1659-1664 [PMID:20117937]
ChEMBL	Competitive inhibition of MAOB in rat liver homogenate by spectrophotometrically	B	4.05	pIC50	89550	nM	IC50	Bioorg Med Chem (2009) 17: 6761-6772 [PMID:19682910]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	F	5.9	pEC50	>1250	nM	EC50	Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	F	6.13	pEC50	>740	nM	EC50	Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity to 5HT1A receptor	B	5.3	pKd	5011.87	nM	Kd	J Med Chem (2009) 52: 6107-6125 [PMID:19754201]
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL	Displacement of [3H]-DTG from S2R in human Jurkat cell membranes after 1 hr in presence of (+)-pentazocine by liquid scintillation counting	B	6.7	pKi	>200	nM	Ki	Eur J Med Chem (2017) 138: 964-978 [PMID:28756263]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Displacement of [3H](+)-pentazocine from S1R in human Jurkat cell membranes after 2 hrs by liquid scintillation counting	B	7	pKi	>100	nM	Ki	Eur J Med Chem (2017) 138: 964-978 [PMID:28756263]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]