birinapant [Ligand Id: 7432] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3039522 (Birinapant, TL-32711, TL32711) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] | ||||||||
| GtoPdb | - | - | 9 | pKd | <1 | nM | Kd | Breast Cancer Res Treat (2013) 137: 359-71 [PMID:23225169] |
| ChEMBL | Binding affinity to cIAP1-BIR3 domain (unknown origin) | B | 9 | pKd | 1 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| ChEMBL | Binding affinity to human N-terminal His-tagged cIAP1 BIR2-3 C202A/C213G mutant after 60 mins by HTRF assay | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2015) 58: 1556-1562 [PMID:25584393] |
| baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] | ||||||||
| ChEMBL | Binding affinity to cIAP2-BIR3 domain (unknown origin) | B | 7.44 | pKd | 36 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| baculoviral IAP repeat containing 7/Baculoviral IAP repeat-containing protein 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075127] [GtoPdb: 2794] [UniProtKB: Q96CA5] | ||||||||
| ChEMBL | Binding affinity to ML-IAP-BIR domain (unknown origin) | B | 9 | pKd | 1 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9] | ||||||||
| ChEMBL | Inhibition of Zika virus NS2B-NS3 protease by cell based assay | B | 6.52 | pEC50 | 300 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126965-126965 [PMID:31980339] |
| X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] | ||||||||
| ChEMBL | Binding affinity to XIAP-BIR3 domain (unknown origin) | B | 7.3 | pKd | 50 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| GtoPdb | - | - | 7.35 | pKd | 45 | nM | Kd | Breast Cancer Res Treat (2013) 137: 359-71 [PMID:23225169] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
