mirabegron [Ligand Id: 7445] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2095212 (Betanis, Betmiga, Mirabegron, Myrbetriq, Myrbetriq granules, YM-178, YM178) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563]; Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | >10000 | nM | EC50 | J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563] |
| GtoPdb | - | - | 5.2 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563]; Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β2-adrenoceptor in Rat [GtoPdb: 29] [UniProtKB: P10608] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| GtoPdb | - | - | 8.8 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563]; Curr Ther Res Clin Exp (2022) 96: 100674 [PMID:35693456]; Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332]; Naunyn Schmiedebergs Arch Pharmacol (2013) 386: 247-53 [PMID:23239087] |
| β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962] | ||||||||
| GtoPdb | - | - | 7.8 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| GtoPdb | - | - | 9.3 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255] | ||||||||
| GtoPdb | - | - | 7.7 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
