glycopyrrolate [Ligand Id: 7459] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1201335 (Glycopyrrolate cation, Glycopyrrolate ion, Glycopyrronium, Glycopyrronium cation, Glycopyrronium, erythro-, Glycopyrronium ion) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| GtoPdb | - | - | 9.5 | pIC50 | - | - | IC50 |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| ChEMBL | Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs | B | 9.8 | pIC50 | 0.16 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 7440-7446 [PMID:22047691] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs | B | 9.6 | pIC50 | 0.25 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 7440-7446 [PMID:22047691] |
| GtoPdb | Assay uses glycopyrronium bromide | - | 9.8 | pIC50 | - | - | IC50 |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| ChEMBL | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method | B | 9.9 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6248-6253 [PMID:24144851] |
| M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| GtoPdb | Assay uses glycopyrronium bromide | - | 10.1 | pIC50 | - | - | IC50 |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| GtoPdb | - | - | 10 | pKi | - | - | - |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| GtoPdb | - | - | 9.9 | pKi | - | - | - |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
