arformoterol [Ligand Id: 7479] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1363 (Arformoterol, Formoterol r,r-form) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology | F | 6.96 | pEC50 | 109 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology | F | 8.58 | pEC50 | 2.63 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| ChEMBL | Agonist activity at beta2-adrenergic receptor (unknown origin) | F | 9.5 | pEC50 | 0.32 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction | B | 9.89 | pEC50 | 0.13 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734] |
| ChEMBL | Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction | B | 9.9 | pEC50 | 0.13 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
