bufexamac [Ligand Id: 7498] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL94394 (Anderm, Bufexamac, Butoxyphenylacethydroxamic acid, CP 1044 J3, CP-1044-J3, Duradermal, NSC-758153, Paraderm, Parfenac) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
| ChEMBL | 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes | F | 4.46 | pIC50 | 35000 | nM | IC50 | J Med Chem (1997) 40: 2780-2787 [PMID:9276024] |
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) | B | 4.57 | pIC50 | 27000 | nM | IC50 | J Med Chem (1990) 33: 992-998 [PMID:2308149] |
| ChEMBL | Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) | B | 6.89 | pIC50 | 128.82 | nM | IC50 | J Med Chem (1990) 33: 992-998 [PMID:2308149] |
| histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| GtoPdb | - | - | 4.91 | pKd | 12300 | nM | Kd | Nat Biotechnol (2011) 29: 255-65 [PMID:21258344] |
| ChEMBL | Inhibition of HDAC10 (unknown origin) | B | 4.91 | pKd | 12300 | nM | Kd | J Med Chem (2013) 56: 6297-6313 [PMID:23627282] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| GtoPdb | - | - | 4.97 | pKd | 10700 | nM | Kd | Nat Biotechnol (2011) 29: 255-65 [PMID:21258344] |
| ChEMBL | Inhibition of HDAC6 (unknown origin) | B | 4.97 | pKd | 10700 | nM | Kd | J Med Chem (2013) 56: 6297-6313 [PMID:23627282] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay | F | 5.56 | pIC50 | 2771 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
