ChEMBL ligand: CHEMBL181633 (AM-630)
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] CB2 receptor/Cannabinoid CB2 receptor in Mouse [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Binding affinity to cannabinoid CB1 receptor	B	5.29	pKi	5152	nM	Ki	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Displacement of [3H]CP 55940 from human CB1 receptor in cell free system	B	5.29	pKi	5152	nM	Ki	Eur J Med Chem (2011) 46: 547-555 [PMID:21183257]
ChEMBL	Inverse agonist activity at human CB1 receptor	F	5.29	pKi	5152	nM	Ki	Eur J Med Chem (2018) 145: 770-789 [PMID:29407590]
ChEMBL	Displacement of [3H]-CP-55940 from human CB1 expressed in CHO cells after 90 mins by TopCount scintillation counting method	B	6	pKi	>1000	nM	Ki	Eur J Med Chem (2018) 146: 68-78 [PMID:29360044]
ChEMBL	Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells	B	6.08	pKi	840	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6505-6510 [PMID:17942307]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL	Displacement of [3H]-CP-55940 from human CB2 expressed in CHO cells after 90 mins by TopCount scintillation counting method	B	7.04	pKi	91	nM	Ki	Eur J Med Chem (2018) 146: 68-78 [PMID:29360044]
ChEMBL	Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells	B	7.44	pKi	36	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6505-6510 [PMID:17942307]
GtoPdb	-	-	7.5	pKi	31.6	nM	Ki	Br J Pharmacol (1999) 126: 665-672 [PMID:10188977]
ChEMBL	Displacement of [3H]CP 55940 from human CB2 receptor in cell free system	B	7.51	pKi	31.2	nM	Ki	Eur J Med Chem (2011) 46: 547-555 [PMID:21183257]
ChEMBL	Inverse agonist activity at CB2 receptor (unknown origin)	B	7.51	pKi	31.2	nM	Ki	Eur J Med Chem (2016) 124: 17-35 [PMID:27560280]
ChEMBL	Inverse agonist activity at human CB2 receptor	F	7.51	pKi	31.2	nM	Ki	Eur J Med Chem (2018) 145: 770-789 [PMID:29407590]
ChEMBL	Binding affinity for human cannabinoid receptor 2 was determined by using [3H]CP-55940 as radioligand	B	7.51	pKi	31.2	nM	Ki	Bioorg Med Chem Lett (2005) 15: 783-786 [PMID:15664857]
ChEMBL	Displacement of [3H]CP55940 from recombinant human CB2R expressed in HEK293 cell membranes measured after 90 mins	B	7.51	pKi	31.2	nM	Ki	Eur J Med Chem (2019) 161: 239-251 [PMID:30359820]
ChEMBL	Binding affinity to cannabinoid CB2 receptor	B	7.51	pKi	31.2	nM	Ki	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Antagonist activity at cannabinoid CB2 receptor	F	5.14	pIC50	7200	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Inverse agonist activity at recombinant human CB2R expressed in CHOK1 cells assessed as increase in NKH477-stimulated intracellular cAMP levels after 30 mins by chemiluminescent based cAMP Hunter assay	F	5.5	pEC50	3150	nM	EC50	J Med Chem (2020) 63: 7369-7391 [PMID:32515588]
ChEMBL	Inverse agonist activity at human CB2 receptor expressed in Sf9 cells coexpressing Galpha i2 assessed as Galpha GTPase activity using [gamma-33P]GTP by scintillation counting in presence of CP55940	B	6.22	pEC50	602.56	nM	EC50	Bioorg Med Chem (2014) 22: 3938-3946 [PMID:24984935]
ChEMBL	Agonist activity at human CB2 receptor expressed in CHO cell membranes after 90 mins by [35S]GTPgammaS binding assay	F	6.78	pEC50	167	nM	EC50	Eur J Med Chem (2018) 154: 155-171 [PMID:29793210]
ChEMBL	Agonist activity at human CB2 receptor expressed CHO cells by [35S]GTPgamma binding assay	F	7.12	pEC50	76.6	nM	EC50	J Med Chem (2009) 52: 433-444 [PMID:19115816]
CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936]
ChEMBL	Inverse agonist activity at mouse CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 5 mins by fluorescence assay	F	7.6	pEC50	25	nM	EC50	J Med Chem (2018) 61: 9841-9878 [PMID:29939744]
ChEMBL	Inverse agonist activity at C-terminally prolink-tagged mouse CB2 receptor expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin recruitment after 90 mins by chemiluminescent assay	B	8.05	pEC50	9	nM	EC50	J Med Chem (2018) 61: 9841-9878 [PMID:29939744]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]