BIC1 [Ligand Id: 7510] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1738777 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bromodomain containing 2/Bromodomain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440] | ||||||||
| GtoPdb | Binding to recombinant BRD2-BD1 protein. | - | 4.55 | pKd | 28000 | nM | Kd | Chem Biol (2011) 18: 495-507 [PMID:21513886] |
| ChEMBL | Binding affinity to BRD2-BD1 by SPR spectroscopy | B | 4.55 | pKd | 28000 | nM | Kd | Bioorg Med Chem (2012) 20: 1887-1892 [PMID:22316554] |
| ChEMBL | Binding affinity to BRD2 isoform 1 by SPR | B | 4.55 | pKd | 28000 | nM | Kd | J Med Chem (2012) 55: 9393-9413 [PMID:22924434] |
| ChEMBL | Inhibition of first bromodomain of BRD2 (unknown origin) | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2013) 56: 8073-8088 [PMID:24090311] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
