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ChEMBL ligand: CHEMBL1828986 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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bromodomain containing 2/Bromodomain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440] | ||||||||
ChEMBL | Displacement of H4Ac4 peptide from first bromodomain of human BRD2 by peptide displacement assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2011) 54: 6761-6770 [PMID:21851057] |
GtoPdb | Inhibition of binding to recombinant BRD2-BD1. | - | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2011) 54: 6761-70 [PMID:21851057] |
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
ChEMBL | Displacement of H4Ac4 peptide from first bromodomain of human BRD4 by peptide displacement assay | B | 5.32 | pIC50 | 4800 | nM | IC50 | J Med Chem (2011) 54: 6761-6770 [PMID:21851057] |
ChEMBL | Binding affinity to human BRD4 bromodomain 1 using H4Ac4 peptide by amplified luminescent proximity homogeneous assay | B | 5.32 | pIC50 | 4800 | nM | IC50 | J Med Chem (2013) 56: 3217-3227 [PMID:23517011] |
ChEMBL | Binding affinity to human BRD4 bromodomain 1 using H4Ac4 peptide by amplified luminescent proximity homogeneous assay | B | 5.32 | pIC50 | 4786.3 | nM | IC50 | J Med Chem (2013) 56: 3217-3227 [PMID:23517011] |
GtoPdb | Inhibition of binding to recombinant BRD4-BD1. | - | 5.32 | pIC50 | 4800 | nM | IC50 | J Med Chem (2011) 54: 6761-70 [PMID:21851057] |
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793] | ||||||||
ChEMBL | Displacement of H3K56Ac from human CREBBP by peptide displacement assay | B | 4.55 | pIC50 | 28100 | nM | IC50 | J Med Chem (2011) 54: 6761-6770 [PMID:21851057] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]