AZD1656 [Ligand Id: 7701] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3219124 (Azd 1656, Azd-1656, Azd1656, AZD1656)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4 pIC50 >100000 nM IC50 Medchemcomm (2012) 3: 1077-1081
Glucokinase/Hexokinase type IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3820] [GtoPdb: 2798] [UniProtKB: P35557]
ChEMBL Binding affinity to biotinylated human recombinant glucokinase expressed in Escherichia coli assessed as dissociation rate constant by SPR method B 7.97 pKd 10.8 nM Kd Medchemcomm (2014) 5: 802-807
ChEMBL Inhibition of recombinant human pancreatic glucokinase by G-6-P dehydrogenase assay B 7.21 pEC50 61 nM EC50 Medchemcomm (2012) 3: 1077-1081
GtoPdb - - 7.24 pEC50 57 nM EC50 AZD1656.. astrazeneca.com
ChEMBL Activation of recombinant human glucokinase assessed as formation of glucose-6-phosphate by G6PDH/NADP coupled assay B 7.55 pEC50 28 nM EC50 Medchemcomm (2014) 5: 802-807

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]