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ChEMBL ligand: CHEMBL1829433 (Azd 4877, Azd-4877, AZD-4877, AZD4877) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kinesin-1 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5864] [UniProtKB: P33176] | ||||||||
ChEMBL | Inhibition of human GST-conventional kinesin ATPase activity after 20 mins by malachite green assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
kinesin-5/Kinesin-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4581] [GtoPdb: 2788] [UniProtKB: P52732] | ||||||||
ChEMBL | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | B | 6.37 | pIC50 | 429 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
ChEMBL | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
GtoPdb | Measured as inhibition of ATPase activity of a 369 amino acid N-terminal fragment of hKIF11 | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2011) 54: 6734-50 [PMID:21899292] |
Kinesin-like protein KIF23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5899] [UniProtKB: Q02241] | ||||||||
ChEMBL | Inhibition of human recombinant GST-MKLP1 after 20 mins by malachite green assay | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]