AZD4877 [Ligand Id: 7708] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1829433 (Azd 4877, Azd-4877, AZD-4877, AZD4877)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kinesin-1 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5864] [UniProtKB: P33176]
ChEMBL Inhibition of human GST-conventional kinesin ATPase activity after 20 mins by malachite green assay B 4 pIC50 >100000 nM IC50 J Med Chem (2011) 54: 6734-6750 [PMID:21899292]
kinesin-5/Kinesin-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4581] [GtoPdb: 2788] [UniProtKB: P52732]
ChEMBL Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay B 6.37 pIC50 429 nM IC50 J Med Chem (2011) 54: 6734-6750 [PMID:21899292]
ChEMBL Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay B 8.7 pIC50 2 nM IC50 J Med Chem (2011) 54: 6734-6750 [PMID:21899292]
GtoPdb Measured as inhibition of ATPase activity of a 369 amino acid N-terminal fragment of hKIF11 - 8.7 pIC50 2 nM IC50 J Med Chem (2011) 54: 6734-50 [PMID:21899292]
Kinesin-like protein KIF23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5899] [UniProtKB: Q02241]
ChEMBL Inhibition of human recombinant GST-MKLP1 after 20 mins by malachite green assay B 4.3 pIC50 50000 nM IC50 J Med Chem (2011) 54: 6734-6750 [PMID:21899292]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]