ChEMBL ligand: CHEMBL3092413
GPR39/G-protein coupled receptor 39 in Human [ChEMBL: CHEMBL3091266] [GtoPdb: 105] [UniProtKB: O43194] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3B/Phosphodiesterase 3B in Human [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR39/G-protein coupled receptor 39 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3091266] [GtoPdb: 105] [UniProtKB: O43194]
ChEMBL	Agonist activity at recombinant human GPR39 expressed in CHO-K1 cells assessed as increase of Zn2+-induced cAMP production preincubated for 30 mins measured after 60 mins	F	4.92	pEC50	12000	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
ChEMBL	Agonist activity at GPR39 in human HT-29 cells assessed as increase in intracellular Ca2+ mobilization after 72 hrs by FLIPR assay	F	6.05	pEC50	900	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
GtoPdb	-	-	7.2	pEC50	59	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-84 [PMID:24900608]
ChEMBL	Agonist activity at recombinant human GPR39 expressed in CHO-K1 cells assessed as increase of Zn2+-induced intracellular Ca+2 mobilization after 1 hr by Fluo-4 No staining-based FLIPR assay	B	7.25	pEC50	56	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL	Inhibition of PDE3a (unknown origin)	B	4.82	pIC50	15000	nM	IC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
phosphodiesterase 3B/Phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
ChEMBL	Inhibition of PDE3B (unknown origin)	B	4.62	pIC50	24000	nM	IC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]