compound 23n [PMID: 24900877] [Ligand Id: 7832] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3287898
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907]
  • diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Mouse [ChEMBL: CHEMBL1075284] [GtoPdb: 2821] [UniProtKB: Q9Z2A7]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Inhibition of CB1 receptor (unknown origin) B 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790]
ChEMBL Inhibition of CASP8 (unknown origin) B 5.17 pIC50 6800 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
Caspase 9/Caspase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2273] [GtoPdb: 1625] [UniProtKB: P55211]
ChEMBL Inhibition of CASP9 (unknown origin) B 5.3 pIC50 5000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907]
GtoPdb - - 7.19 pIC50 64 nM IC50 ACS Med Chem Lett (2014) 5: 544-9 [PMID:24900877]
ChEMBL Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis B 7.19 pIC50 64 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075284] [GtoPdb: 2821] [UniProtKB: Q9Z2A7]
ChEMBL Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis B 7.36 pIC50 44 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Inhibition of D2 receptor (unknown origin) B 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGF receptor (unknown origin) B 5.12 pIC50 7500 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of insulin receptor (unknown origin) B 5.24 pIC50 5700 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Inhibition of prostanoid IP receptor (unknown origin) B 6 pIC50 1000 nM IC50 ACS Med Chem Lett (2014) 5: 544-549 [PMID:24900877]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]