BMS-582949 [Ligand Id: 7838] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1230065 (Bms 582949, Bms-582949, BMS-582949, Ps-540446, PS-540446) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2010) 53: 6629-6639 [PMID:20804198] |
| ChEMBL | Inhibition of P38alpha MAPK (unknown origin) | B | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2019) 182: 111624-111624 [PMID:31445234] |
| GtoPdb | - | - | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2010) 53: 6629-39 [PMID:20804198] |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Inhibition of p38beta (unknown origin) | B | 7.21 | pIC50 | 62 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4120-4126 [PMID:23746475] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
