ChEMBL ligand: CHEMBL2347211
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
beta-secretase 2/Beta secretase 2 in Human [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
GtoPdb	-	-	7.74	pIC50	18	nM	IC50	Cell Metab (2011) 14: 365-77 [PMID:21907142]
ChEMBL	Inhibition of recombinant human BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by fluorescence assay	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2033-2045 [PMID:24704031]
ChEMBL	Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis	B	7.8	pIC50	16	nM	IC50	J Med Chem (2013) 56: 3980-3995 [PMID:23590342]
ChEMBL	Inhibition of BACE1 (unknown origin)	B	8.17	pIC50	6.7	nM	IC50	J Med Chem (2018) 61: 5122-5137 [PMID:29733614]
ChEMBL	Inhibition of BACE1 (1 to 454 residues) (unknown origin) using Mca-APP Swedish Lys-Met/Asn-Leu mutant-Dnp quencher as substrate by fluorescence assay	B	8.34	pIC50	4.6	nM	IC50	J Med Chem (2019) 62: 5080-5095 [PMID:31021626]
ChEMBL	Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as reduction of amyloid beta40 level after 18 to 20 hrs by AlphaLISA technique	B	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3980-3995 [PMID:23590342]
ChEMBL	Inhibition of BACE1 in human SKNBE2 cells expressing APP695 assessed as reduction in Abeta42 level measured after 18 hrs by sandwich ELISA	B	9.03	pIC50	0.93	nM	IC50	J Med Chem (2019) 62: 5080-5095 [PMID:31021626]
ChEMBL	Inhibition of BACE1 (unknown origin) assessed as reduction in amyloid beta production by cell based assay	B	9.08	pIC50	0.84	nM	IC50	J Med Chem (2018) 61: 5122-5137 [PMID:29733614]
beta-secretase 2/Beta secretase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0]
ChEMBL	Inhibition of human BACE2 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis	B	8.05	pIC50	9	nM	IC50	J Med Chem (2013) 56: 3980-3995 [PMID:23590342]
GtoPdb	-	-	8.22	pIC50	6	nM	IC50	Cell Metab (2011) 14: 365-77 [PMID:21907142]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]