ChEMBL ligand: CHEMBL371064 (AAE-581, AAE581, Balicatib)
cathepsin B/Cathepsin B in Human [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] There should be some charts here, you may need to enable JavaScript!
cathepsin D/Cathepsin D in Human [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] There should be some charts here, you may need to enable JavaScript!
cathepsin K/Cathepsin K in Human [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] Cathepsin K in Rabbit [ChEMBL: CHEMBL3349] [UniProtKB: P43236] There should be some charts here, you may need to enable JavaScript!
cathepsin L/Cathepsin L in Human [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] There should be some charts here, you may need to enable JavaScript!
cathepsin S/Cathepsin S in Human [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] cathepsin S/Cathepsin S in Mouse [ChEMBL: CHEMBL4098] [GtoPdb: 2353] [UniProtKB: O70370] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL	Inhibition of human cathepsin B using Z-Arg-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 mins	B	5.42	pKi	3800	nM	Ki	ACS Med Chem Lett (2014) 5: 1076-1081 [PMID:25313316]
ChEMBL	Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate	B	5.54	pKi	2900	nM	Ki	J Med Chem (2005) 48: 7520-7534 [PMID:16302794]
ChEMBL	Inhibitory activity against human cathepsin B	B	5.32	pIC50	4800	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibition of human recombinant CatB assessed as suppression of enzyme-mediated Z-Arg-Arg-AMC cleavage by QFRET assay	B	5.32	pIC50	4750	nM	IC50	J Med Chem (2012) 55: 6363-6374 [PMID:22742641]
ChEMBL	Inhibitory activity against human cathepsin B expressed in HepG2 cells	B	7.21	pIC50	61	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibition of cathepsin B in human HepG2 cells	B	7.21	pIC50	61	nM	IC50	Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527]
cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339]
ChEMBL	Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 mins	B	8.89	pKi	1.29	nM	Ki	ACS Med Chem Lett (2014) 5: 1076-1081 [PMID:25313316]
cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235]
ChEMBL	Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay	B	8.85	pKi	1.4	nM	Ki	J Med Chem (2015) 58: 6928-6937 [PMID:26280490]
ChEMBL	Inhibition of human recombinant CatK assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage incubated for 1 hrs by QFRET assay	B	8.3	pIC50	5	nM	IC50	J Med Chem (2012) 55: 6363-6374 [PMID:22742641]
ChEMBL	Inhibition of cathepsin-k	B	8.3	pIC50	5	nM	IC50	J Med Chem (2012) 55: 8827-8837 [PMID:22984809]
GtoPdb	-	-	8.85	pIC50	1.4	nM	IC50	J Med Chem (2010) 53: 4332-53 [PMID:20218623]
ChEMBL	Inhibitory activity against humanized rabbit cathepsin K	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibition of cathepsin K	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Inhibition of human cathepsin K	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527]
Cathepsin K in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3349] [UniProtKB: P43236]
ChEMBL	Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate	B	8.85	pKi	1.4	nM	Ki	J Med Chem (2005) 48: 7520-7534 [PMID:16302794]
ChEMBL	Inhibitory activity against rabbit cathepsin K	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibition of rabbit cathepsin K	B	8.57	pIC50	2.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527]
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL	Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate	B	4.74	pKi	18000	nM	Ki	J Med Chem (2005) 48: 7520-7534 [PMID:16302794]
ChEMBL	Inhibition of human cathepsin L using Z-Phe-Arg-pNA chromogenic substrate fluorogenic substrate incubated for 30 mins	B	5.49	pKi	3260	nM	Ki	ACS Med Chem Lett (2014) 5: 1076-1081 [PMID:25313316]
ChEMBL	Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay	B	6.3	pKi	503	nM	Ki	J Med Chem (2015) 58: 6928-6937 [PMID:26280490]
ChEMBL	Inhibitory activity against human cathepsin L	B	6.3	pIC50	503	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibitory activity against human cathepsin L expressed in HepG2 cells	B	7.32	pIC50	48	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibition of cathepsin L in human HepG2 cells	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527]
cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774]
ChEMBL	Inhibition of human cathepsin-S using Z-Phe-Val-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay	B	4.19	pKi	65000	nM	Ki	J Med Chem (2015) 58: 6928-6937 [PMID:26280490]
ChEMBL	Inhibition of human cathepsin S using Z-Phe-Arg-AMC fluorogenic substrate fluorogenic substrate incubated for 60 mins	B	4.52	pKi	30100	nM	Ki	ACS Med Chem Lett (2014) 5: 1076-1081 [PMID:25313316]
ChEMBL	Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate	B	4.55	pKi	28000	nM	Ki	J Med Chem (2005) 48: 7520-7534 [PMID:16302794]
ChEMBL	Inhibitory activity against human cathepsin S	B	4.19	pIC50	65000	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibitory activity against human cathepsin S expressed in ramos cells	B	5.54	pIC50	2900	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibition of cathepsin S in human ramos cells	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527]
cathepsin S/Cathepsin S in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4098] [GtoPdb: 2353] [UniProtKB: O70370]
ChEMBL	Inhibitory activity against mouse cathepsin S	B	5.2	pIC50	6350	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]
ChEMBL	Inhibitory activity against mouse cathepsin S in mouse splenocytes	B	6.32	pIC50	480	nM	IC50	J Med Chem (2005) 48: 7535-7543 [PMID:16302795]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]