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ChEMBL ligand: CHEMBL260880 ([1-Hydroxy-2-(1,1':3',1''-Terphenyl-3-Yloxy)Ethane-1,1-Diyl]Bis(Phosphonic Acid)) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051] | ||||||||
ChEMBL | Binding affinity to Saccharomyces cerevisiae GGPPS | B | 7.22 | pKi | 60 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
ChEMBL | Inhibition of Saccharomyces cerevisiae GGPPS | B | 6.85 | pIC50 | 140 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
ChEMBL | Binding affinity to human GGPPS | B | 6.96 | pKi | 110 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
GtoPdb | - | - | 6.96 | pKi | 110 | nM | Ki | Proc Natl Acad Sci USA (2007) 104: 10022-7 [PMID:17535895] |
ChEMBL | Inhibition of human GGPPS | B | 5.39 | pIC50 | 4100 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 5.39 | pIC50 | 4070 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 5.4 | pIC50 | 3981.07 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]