compound 30 [PMID: 22902653] [Ligand Id: 8118] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2070613
  • testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
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  • testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
ChEMBL Inhibition of TESK1 B 5.66 pIC50 2198 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb - - 5.95 pIC50 1133 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
GtoPdb - - 6.38 pIC50 415 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL Inhibition of TESK2 B 6.38 pIC50 415 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL Inhibition of LIMK1 B 7.18 pIC50 66 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb - - 7.64 pIC50 23 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Inhibition of LIMK2 B 6.76 pIC50 173 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb - - 7.8 pIC50 16 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]