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ChEMBL ligand: CHEMBL1774056 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
ChEMBL | Inhibition of human CDK2/cyclinE | B | 6.76 | pIC50 | 174 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
ChEMBL | Inhibition of human EphB2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of human EGFR | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
ChEMBL | Inhibition of human FGFR3 | B | 6.94 | pIC50 | 115 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
GtoPdb | - | - | 6.94 | pIC50 | 115 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of human InsR | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] | ||||||||
ChEMBL | Inhibition of human MuSk | B | 6.65 | pIC50 | 224 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
GtoPdb | - | - | 6.65 | pIC50 | 224 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067] |
ChEMBL | Inhibition of human TRKA | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
ChEMBL | Inhibition of human Pyk2 | B | 6.89 | pIC50 | 129 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 after 60 min | B | 8.52 | pIC50 | <3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
GtoPdb | - | - | 9 | pIC50 | <1 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067] |
ChEMBL | Inhibition of human JAK2 | B | 9 | pIC50 | <1 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067] |
ChEMBL | Inhibition of human JAK3 | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
ChEMBL | Inhibition of JAK3 after 60 min | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of human Lck | B | 6.67 | pIC50 | 215 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
ChEMBL | Inhibition of human FLT3 D835Y mutant | B | 7.09 | pIC50 | 82 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067] |
ChEMBL | Inhibition of human RET | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]