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ChEMBL ligand: CHEMBL2324924 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of P38alpha (unknown origin) | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL | Inhibition of wild type Abl1 kinase (unknown origin) | B | 9.22 | pIC50 | 0.6 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
GtoPdb | - | - | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2013) 56: 3033-47 [PMID:23441572] |
ChEMBL | Inhibition of Abl1 kinase Q252H mutant (unknown origin) | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL | Inhibition of Abl1 kinase T315I mutant (unknown origin) | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL | Inhibition of Abl1 kinase Y253F mutant (unknown origin) | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL | Inhibition of Abl1 kinase M351T mutant (unknown origin) | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL | Inhibition of Abl1 kinase H396P mutant (unknown origin) | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL | Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] | ||||||||
ChEMBL | Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2013) 56: 3033-47 [PMID:23441572] |
ChEMBL | Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2013) 56: 3033-3047 [PMID:23441572] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]