ChEMBL ligand: CHEMBL2010872 (BOL-303213X, Cep 11981, Cep-11981, CEP-11981, CEP11981)
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] There should be some charts here, you may need to enable JavaScript!
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] There should be some charts here, you may need to enable JavaScript!
casein kinase 1 alpha 1/Casein kinase I alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] There should be some charts here, you may need to enable JavaScript!
Testicular receptor 4/Nuclear receptor subfamily 2 group C member 2 in Human [ChEMBL: CHEMBL5716] [GtoPdb: 614] [UniProtKB: P49116] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] There should be some charts here, you may need to enable JavaScript!
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] There should be some charts here, you may need to enable JavaScript!
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451] BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Mouse [ChEMBL: CHEMBL3343] [GtoPdb: 1940] [UniProtKB: P16277] There should be some charts here, you may need to enable JavaScript!
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Inhibition of adenosine A2A receptor	B	6.3	pKi	500	nM	Ki	J Med Chem (2012) 55: 903-913 [PMID:22148921]
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL	Inhibition of human ALK using ATP as substrate	B	6.88	pIC50	132	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL	Inhibition of CK1 using ATP as substrate	B	7.32	pIC50	48	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	Inhibition of human FGFR1 using ATP as substrate	B	7.89	pIC50	13	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
GtoPdb	-	-	7.89	pIC50	13	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL	Inhibition of human FGFR3 using ATP as substrate	B	7.05	pIC50	89	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human Erg expressed CHO cells	B	4.7	pIC50	20000	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
ChEMBL	Inhibition of human FMS using ATP as substrate	B	7.11	pIC50	78	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Inhibition of muscarinic M4 receptor	B	5.54	pKi	2900	nM	Ki	J Med Chem (2012) 55: 903-913 [PMID:22148921]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
GtoPdb	-	-	8.52	pIC50	3	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
ChEMBL	Inhibition of human TRK-A using ATP as substrate	B	8.52	pIC50	3	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
GtoPdb	-	-	8.3	pIC50	5	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
ChEMBL	Inhibition of human TRK-B using ATP as substrate	B	8.3	pIC50	5	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
Testicular receptor 4/Nuclear receptor subfamily 2 group C member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5716] [GtoPdb: 614] [UniProtKB: P49116]
ChEMBL	Inhibition of human TAK1 using ATP as substrate	B	7.85	pIC50	14	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL	Inhibition of human PDGFRalpha using ATP as substrate	B	6.61	pIC50	246	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Inhibition of human Aurora-A using ATP as substrate	B	7.38	pIC50	42	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL	Inhibition of human CHK2 using ATP as substrate	B	6.85	pIC50	140	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
ChEMBL	Inhibition of human MST2 using ATP as substrate	B	7.68	pIC50	21	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
GtoPdb	-	-	7.68	pIC50	21	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
GtoPdb	-	-	8.1	pIC50	8	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3343] [GtoPdb: 1940] [UniProtKB: P16277]
ChEMBL	Inhibition of mouse BLK using ATP as substrate	B	8.1	pIC50	8	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL	Inhibition of human BTK using ATP as substrate	B	7.03	pIC50	93	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL	Inhibition of human FLT3 using ATP as substrate	B	7.15	pIC50	71	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb	-	-	8.3	pIC50	5	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
ChEMBL	Inhibition of human RET using ATP as substrate	B	8.3	pIC50	5	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of human cSrc using ATP as substrate	B	7.43	pIC50	37	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL	Inhibition of human Tie2 expressed in porcine PAE145 cells cotransfected with chimeric rat TRK-A/KDR receptor after 1 hr by immunofluorescence assay	B	7.3	pIC50	50	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
GtoPdb	-	-	7.59	pIC50	26	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
ChEMBL	Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluorescence analysis	B	7.66	pIC50	22	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
GtoPdb	-	-	8.52	pIC50	3	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
ChEMBL	Inhibition of human VEGFR1 using ATP as substrate	B	8.52	pIC50	3	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of human VEGFR2 expressed in porcine PAE145 cells cotransfected with chimeric rat TRK-A/KDR receptor after 1 hr by immunofluorescence assay	B	8	pIC50	<10	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
ChEMBL	Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluorescence analysis	B	8.4	pIC50	4	nM	IC50	J Med Chem (2012) 55: 903-913 [PMID:22148921]
GtoPdb	-	-	8.4	pIC50	4	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]
mitogen-activated protein kinase kinase kinase 7 in Human [GtoPdb: 2082] [UniProtKB: O43318]
GtoPdb	-	-	7.85	pIC50	14	nM	IC50	J Med Chem (2012) 55: 903-13 [PMID:22148921]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]