compound 8 [PMID: 24044867] [Ligand Id: 8195] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2436980
  • leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
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  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Mouse [ChEMBL: CHEMBL2434817] [GtoPdb: 2071] [UniProtKB: Q80XI6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL Inhibition of human wild type LRRK2 by qPCR analysis B 7.46 pIC50 35 nM IC50 J Med Chem (2013) 56: 8032-8048 [PMID:24044867]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
GtoPdb - - 8.52 pIC50 3 nM IC50 J Med Chem (2013) 56: 8032-48 [PMID:24044867]
ChEMBL Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATP B 8.52 pIC50 3 nM IC50 J Med Chem (2013) 56: 8032-8048 [PMID:24044867]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434817] [GtoPdb: 2071] [UniProtKB: Q80XI6]
ChEMBL Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISA B 5.57 pIC50 2700 nM IC50 J Med Chem (2013) 56: 8032-8048 [PMID:24044867]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]