A-443654 [Ligand Id: 8204] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL379300 (A-443654, A-4436554) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of Akt1 in presence of 10 uM ATP | B | 9.8 | pKi | 0.16 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 3740-3744 [PMID:16678413] |
| ChEMBL | Inhibition of AKT1 | B | 9.8 | pKi | 0.16 | nM | Ki | Nat Chem Biol (2009) 5: 484-493 [PMID:19465931] |
| GtoPdb | - | - | 9.8 | pKi | 0.16 | nM | Ki | Mol Cancer Ther (2005) 4: 977-86 [PMID:15956255] |
| ChEMBL | Inhibition of myristoylated wild type AKT1 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Nat Chem Biol (2009) 5: 484-493 [PMID:19465931] |
| ChEMBL | Inhibition of human Akt1 | B | 9.8 | pIC50 | 0.16 | nM | IC50 | J Med Chem (2007) 50: 2990-3003 [PMID:17523610] |
| ChEMBL | Inhibition of Akt | B | 9.8 | pIC50 | 0.16 | nM | IC50 | Eur J Med Chem (2009) 44: 4090-4097 [PMID:19497644] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| GtoPdb | - | - | 9.8 | pKi | ~0.16 | nM | Ki | Mol Cancer Ther (2005) 4: 977-86 [PMID:15956255] |
| ChEMBL | Inhibition of myristoylated wild type AKT2 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | B | 7.52 | pIC50 | 30 | nM | IC50 | Nat Chem Biol (2009) 5: 484-493 [PMID:19465931] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| GtoPdb | - | - | 9.8 | pKi | ~0.16 | nM | Ki | Mol Cancer Ther (2005) 4: 977-86 [PMID:15956255] |
| ChEMBL | Inhibition of myristoylated wild type AKT3 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | B | 7.29 | pIC50 | 51 | nM | IC50 | Nat Chem Biol (2009) 5: 484-493 [PMID:19465931] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
