compound 1 [PMID: 24793884] [Ligand Id: 8218] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3261228 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7] | ||||||||
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.188 uM of ATP as substrate by AlphaScreen assay | B | 6.26 | pIC50 | 547 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.375 uM of ATP as substrate by AlphaScreen assay | B | 6.26 | pIC50 | 546 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.094 uM of ATP as substrate by AlphaScreen assay | B | 6.28 | pIC50 | 528 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 3 uM of ATP as substrate by AlphaScreen assay | B | 6.38 | pIC50 | 419 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.047 uM of ATP as substrate by AlphaScreen assay | B | 6.39 | pIC50 | 405 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| GtoPdb | - | - | 6.49 | pIC50 | 323 | nM | IC50 | Eur J Med Chem (2014) 80: 364-82 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay | B | 6.49 | pIC50 | 323 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 1.5 uM of ATP as substrate by AlphaScreen assay | B | 6.5 | pIC50 | 318 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.75 uM of ATP as substrate by AlphaScreen assay | B | 6.5 | pIC50 | 316 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.023 uM of ATP as substrate by AlphaScreen assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
