ChEMBL ligand: CHEMBL3261514
casein kinase 1 alpha 1/Casein kinase I alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] There should be some charts here, you may need to enable JavaScript!
casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 9/CDK9/cyclin T1 in Human [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] There should be some charts here, you may need to enable JavaScript!
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL	Inhibition of CK1alpha (unknown origin) by TR-FRET assay	B	6.16	pIC50	694	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL	Inhibition of CK1delta (unknown origin) by TR-FRET assay	B	7.08	pIC50	84	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Inhibition of CK2 (unknown origin) by homogeneous time-resolved fluorescence assay	B	4.54	pIC50	29100	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7]
ChEMBL	Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs	B	6.3	pIC50	501	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 54 uM of ATP as substrate by AlphaScreen assay	B	7.07	pIC50	86	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.074 uM of ATP as substrate by AlphaScreen assay	B	7.19	pIC50	64	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.037 uM of ATP as substrate by AlphaScreen assay	B	7.2	pIC50	63	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 27 uM of ATP as substrate by AlphaScreen assay	B	7.36	pIC50	44	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.025 uM of ATP as substrate by AlphaScreen assay	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.222 uM of ATP as substrate by AlphaScreen assay	B	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.111 uM of ATP as substrate by AlphaScreen assay	B	7.54	pIC50	29	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 18 uM of ATP as substrate by AlphaScreen assay	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.333 uM of ATP as substrate by AlphaScreen assay	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 9 uM of ATP as substrate by AlphaScreen assay	B	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.012 uM of ATP as substrate by AlphaScreen assay	B	7.77	pIC50	17	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.667 uM of ATP as substrate by AlphaScreen assay	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 6 uM of ATP as substrate by AlphaScreen assay	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 1 uM of ATP as substrate by AlphaScreen assay	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 2 uM of ATP as substrate by AlphaScreen assay	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
GtoPdb	-	-	8.42	pIC50	3.77	nM	IC50	Eur J Med Chem (2014) 80: 364-82 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay	B	8.42	pIC50	3.77	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750]
ChEMBL	Inhibition of CDK9/Cyclin-T1 (unknown origin) by homogeneous time-resolved fluorescence assay	B	6.13	pIC50	749	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635]
ChEMBL	Inhibition of CDK1/Cyclin-B (unknown origin) by homogeneous time-resolved fluorescence assay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941]
ChEMBL	Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay	B	5.74	pIC50	1820	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385]
ChEMBL	Inhibition of CDK4/Cyclin-D1 (unknown origin) by homogeneous time-resolved fluorescence assay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL	Inhibition of Pim1 (unknown origin) by homogeneous time-resolved fluorescence assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]