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ChEMBL ligand: CHEMBL505896 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of JNK2 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Inhibition of CDK5 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
ChEMBL | Inhibition of FGFRK2 | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of cMet by HTRF assay | B | 8.05 | pKi | 8.9 | nM | Ki | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
ChEMBL | Inhibition of human c-MET | B | 7.77 | pIC50 | 17 | nM | IC50 | Eur J Med Chem (2011) 46: 3675-3680 [PMID:21641696] |
GtoPdb | - | - | 7.77 | pIC50 | 17 | nM | IC50 | J Biol Chem (2008) 283: 2675-83 [PMID:18055465] |
ChEMBL | Inhibition of c-Met by HTRF assay | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2008) 51: 2879-2882 [PMID:18426196] |
ChEMBL | Inhibition of wild type GST-tagged c-Met kinase domain (1058 to 1365) (unknown origin) expressed in Sf9 cells by HTRF assay | B | 8.05 | pIC50 | 8.9 | nM | IC50 | Bioorg Med Chem (2013) 21: 2843-2855 [PMID:23628470] |
ChEMBL | Inhibition of c-Met (unknown origin) | B | 8.05 | pIC50 | 8.9 | nM | IC50 | Eur J Med Chem (2013) 64: 62-73 [PMID:23644189] |
ChEMBL | Inhibition of c-Met (unknown origin) | B | 8.05 | pIC50 | 8.9 | nM | IC50 | Eur J Med Chem (2014) 83: 581-593 [PMID:24996144] |
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
ChEMBL | Inhibition of cFMS kinase | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
ChEMBL | Inhibition of phosphorylated RON | B | 6.71 | pKi | 195 | nM | Ki | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of ERK1 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
ChEMBL | Inhibition of P70S6 | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
ChEMBL | Inhibition of MSK1 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of PKBalpha | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of Aurora2 | B | 6.94 | pIC50 | 116 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of PIM1 kinase | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
ChEMBL | Inhibition of PIM2 kinase | B | 4.6 | pIC50 | >25000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
ChEMBL | Inhibition of BTK | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Inhibition of JAK2 | B | 4.6 | pIC50 | >25000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 | B | 5.08 | pIC50 | >8300 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
ChEMBL | Inhibition of Tie2 kinase | B | 6.55 | pIC50 | 285 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 5.27 | pIC50 | >5400 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
ChEMBL | Inhibition of Flt1 kinase | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of phosphorylated KDR by HTRF assay | B | 6.37 | pKi | 422 | nM | Ki | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of Flt4 kinase | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2008) 51: 5766-5779 [PMID:18763753] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]