CHR-3996 [Ligand Id: 8391] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1801250 (Chr 3996, CHR-3996, Hdac inhibitor chr-3996, Nanatinostat, VRX-3996) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| ChEMBL | Inhibition of human recombinant HDAC1 using fluor de Lys as substrate by fluorometric analysis | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysis | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| ChEMBL | Inhibition of human recombinant HDAC3 using fluor de Lys as substrate by fluorometric analysis | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC5 using fluor de Lys as substrate by fluorometric analysis | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC6 using fluor de Lys as substrate by fluorometric analysis | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| GtoPdb | - | - | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
