ChEMBL ligand: CHEMBL1784369
ADAMTS4 in Human [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173] There should be some charts here, you may need to enable JavaScript!
ADAMTS5 in Human [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ADAMTS4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173]
GtoPdb	-	-	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3301-6 [PMID:21536437]
ChEMBL	Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay	B	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3301-3306 [PMID:21536437]
ADAMTS5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0]
ChEMBL	Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assay	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3301-3306 [PMID:21536437]
GtoPdb	-	-	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3301-6 [PMID:21536437]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]