ChEMBL ligand: CHEMBL3115901
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] There should be some charts here, you may need to enable JavaScript!
coagulation factor XI/Coagulation factor XI in Human [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
protein C, inactivator of coagulation factors Va and VIIIa/Vitamin K-dependent protein C in Human [ChEMBL: CHEMBL4444] [GtoPdb: 2396] [UniProtKB: P04070] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Competitive inhibition of human coagulation factor 10a using S-2765 as substrate	B	4.82	pKi	>15000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
ChEMBL	Inhibition of human coagulation factor 10a using S-2765 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	4.36	pIC50	>44000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
coagulation factor XI/Coagulation factor XI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951]
ChEMBL	Competitive inhibition of human coagulation factor 11a using S-2366 as substrate	B	6.52	pKi	300	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
ChEMBL	Inhibition of human coagulation factor 11a using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	6.24	pIC50	580	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Competitive inhibition of human thrombin using S-2366 as substrate	B	6.3	pKi	500	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
ChEMBL	Inhibition of human thrombin using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
protein C, inactivator of coagulation factors Va and VIIIa/Vitamin K-dependent protein C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4444] [GtoPdb: 2396] [UniProtKB: P04070]
ChEMBL	Competitive inhibition of human APC using S-2366 as substrate	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
GtoPdb	-	-	7.4	pKi	40	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-7 [PMID:24418773]
ChEMBL	Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]