compound 1b [PMID: 18078750] [Ligand Id: 8627] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL163454 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibition of human recombinant ACE by fluorescence assay | B | 6.28 | pKi | 520 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| Angiotensin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1] | ||||||||
| ChEMBL | Inhibition of human recombinant ACE2 by fluorescence assay | B | 5.85 | pKi | 1400 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| Carboxypeptidase A1 (pancreatic)/Carboxypeptidase A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2088] [GtoPdb: 1587] [UniProtKB: P15085] | ||||||||
| ChEMBL | Inhibition of human recombinant carboxy peptidase A1 by fluorescence assay | B | 6.51 | pKi | 310 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| GtoPdb | - | - | 6.51 | pKi | 310 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-7 [PMID:18078750] |
| Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473] | ||||||||
| ChEMBL | Inhibition of human recombinant NEP by fluorescence assay | B | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| GtoPdb | - | - | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-7 [PMID:18078750] |
| Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861] | ||||||||
| ChEMBL | Inhibition of neutral endopeptidase (NEP) 24.11 | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 735-738 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
