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ChEMBL ligand: CHEMBL287423 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
GtoPdb | - | - | 7.74 | pKi | 18 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
ChEMBL | Binding affinity against human cathepsin D | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
Cathepsin D in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4106] [UniProtKB: P80209] | ||||||||
ChEMBL | Inhibitory activity against bovine Cathepsin D | B | 6.79 | pIC50 | 164 | nM | IC50 | J Med Chem (1992) 35: 2-14 [PMID:1732531] |
cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] | ||||||||
GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
ChEMBL | Binding affinity against human cathepsin E | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
pepsinogen A5/Pepsin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9] | ||||||||
ChEMBL | Binding affinity against human pepsin | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
GtoPdb | - | - | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
progastricsin/Pepsinogen C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2136] [GtoPdb: 2391] [UniProtKB: P20142] | ||||||||
ChEMBL | Binding affinity against human gastricsin | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
GtoPdb | - | - | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
ChEMBL | The concentration producing 50% inhibition of renin activity in monkey plasma was determined by radioimmunoassay. | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1992) 35: 2-14 [PMID:1732531] |
ChEMBL | Inhibitory activity against monkey renin | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]