compound 51 [PMID: 19743866] [Ligand Id: 8653] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1089597 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| complement factor B/Complement factor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5731] [GtoPdb: 2339] [UniProtKB: P00751] | ||||||||
| ChEMBL | Inhibition of human C3 convertase assessed as inhibition of C3a and C3b fragment production at pH 7.4 after 30 mins by SDS-PAGE | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 6042-6052 [PMID:19743866] |
| GtoPdb | - | - | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2009) 52: 6042-52 [PMID:19743866] |
| ChEMBL | Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assay | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2009) 52: 6042-6052 [PMID:19743866] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
