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ChEMBL ligand: CHEMBL57818 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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peptidyl arginine deiminase 1/Protein-arginine deiminase type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909486] [GtoPdb: 2894] [UniProtKB: Q9ULC6] | ||||||||
ChEMBL | Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay | B | 6.02 | pIC50 | 950 | nM | IC50 | Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480] |
Protein-arginine deiminase type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909487] [UniProtKB: Q9Y2J8] | ||||||||
ChEMBL | Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by COLDER assay | B | 5.09 | pKi | 8080 | nM | Ki | Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480] |
ChEMBL | Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480] |
peptidyl arginine deiminase 3/Protein-arginine deiminase type-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909488] [GtoPdb: 2878] [UniProtKB: Q9ULW8] | ||||||||
ChEMBL | Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480] |
peptidyl arginine deiminase 4/Protein-arginine deiminase type-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6111] [GtoPdb: 2877] [UniProtKB: Q9UM07] | ||||||||
ChEMBL | Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by COLDER assay | B | 4.7 | pKi | 20100 | nM | Ki | Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480] |
ChEMBL | Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem (2014) 22: 1362-1369 [PMID:24440480] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]