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ChEMBL ligand: CHEMBL1129 (F3dthd, NSC-529182, NSC-75520, T.f.t., Trifluridine, Trifluridine, Triherpine, Viroptic) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Thymidine kinase in Macacine herpesvirus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075062] [UniProtKB: A3RLP8] | ||||||||
ChEMBL | Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation | B | 5.7 | pIC50 | 2000 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 2028-2034 [PMID:17438061] |
Thymidylate kinase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2361] [UniProtKB: P9WKE1] | ||||||||
ChEMBL | Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis | B | 4.01 | pKi | 97000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 3045-3048 [PMID:12941330] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]