compound 27 [PMID: 22142545] [Ligand Id: 8757] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1940053 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-9 [PMID:22142545] |
| ChEMBL | Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assay | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| ChEMBL | Inhibition of human recombinant PDE10A assessed as hydrolysis of cAMP to AMP using [3H]cAMP substrate by scintillation proximity assay | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 1335-1339 [PMID:22227212] |
| phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE11A3 by competitive binding assay | B | 5.8 | pKi | 1600 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE1A3 by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE2A by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE3A by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE4B2 by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE5A1 by competitive binding assay | B | 5.01 | pKi | 9700 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE7A1 by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE8A1 by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
| phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] | ||||||||
| ChEMBL | Displacement of [3H]cAMP from PDE9A1 by competitive binding assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 235-239 [PMID:22142545] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
