ChEMBL ligand: CHEMBL290376 (DuP-714)
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] Thrombin in Bovine [ChEMBL: CHEMBL4471] [UniProtKB: P00735] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
serine protease 1/Trypsin I in Human [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	In vitro for inhibition of plasmin	B	8.29	pKi	5.1	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Binding affinity against Thrombin.	B	10.39	pKd	0.04	nM	Kd	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of Coagulation factor II	B	10.38	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1999) 9: 925-930 [PMID:10230612]
ChEMBL	Inhibition constant for binding with thrombin was determined	B	10.39	pKi	0.04	nM	Ki	J Med Chem (1993) 36: 1831-1838 [PMID:8515421]
ChEMBL	In vitro for inhibition of thrombin.	B	10.39	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
GtoPdb	Affinity for thrombin active site.	-	10.39	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913–2918
ChEMBL	Inhibition of thrombin	B	10.4	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1997) 7: 1595-1600
ChEMBL	Inhibition of compound against thrombin mediated platelet activation and fibrinogen cleavage.	B	10.4	pKi	0.04	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735]
ChEMBL	Concentration necessary to double time for clot formation induced by bovine thrombin	B	7.26	pKi	55	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
GtoPdb	-	-	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913–2918
ChEMBL	Compound was tested in vitro for inhibition of tissue plasminogen activator	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
ChEMBL	Inhibitory activity against trypsin	B	8.05	pKi	9	nM	Ki	Bioorg Med Chem Lett (1999) 9: 925-930 [PMID:10230612]
ChEMBL	Inhibition of trypsin	B	10.35	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1997) 7: 1595-1600
ChEMBL	Binding affinity against Trypsin	B	10.35	pKi	0.04	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Compound was tested in vitro for inhibition of trypsin	B	10.35	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]