compound 10h [PMID: 20832306] [Ligand Id: 8779] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1258253
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  • Malonyl-CoA decarboxylase in Human [GtoPdb: 1275] [UniProtKB: O95822]
  • Malonyl-CoA decarboxylase/Malonyl-CoA decarboxylase, mitochondrial in Mouse [ChEMBL: CHEMBL1255162] [GtoPdb: 1275] [UniProtKB: Q99J39]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Malonyl-CoA decarboxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4698] [GtoPdb: 1275] [UniProtKB: O95822]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem Lett (2010) 20: 6088-92 [PMID:20832306]
ChEMBL Inhibition of human MCD B 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem Lett (2010) 20: 6088-6092 [PMID:20832306]
Malonyl-CoA decarboxylase in Human [GtoPdb: 1275] [UniProtKB: O95822]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem Lett (2010) 20: 6088-92 [PMID:20832306]
Malonyl-CoA decarboxylase/Malonyl-CoA decarboxylase, mitochondrial in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255162] [GtoPdb: 1275] [UniProtKB: Q99J39]
ChEMBL Inhibition of MCD in mouse hepatocytes by whole cell assay B 6.82 pEC50 150 nM EC50 Bioorg Med Chem Lett (2010) 20: 6088-6092 [PMID:20832306]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]