compound 1b [PMID: 9871762] [Ligand Id: 8794] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL281025 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| squalene monooxygenase/Squalene monooxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534] | ||||||||
| ChEMBL | In vitro inhibition of dog liver squalene epoxidase in HepG2 cells | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1337-1342 [PMID:9871762] |
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1337-42 [PMID:9871762] |
| ChEMBL | In vitro inhibition of cholesterol biosynthesis in human HepG2 cells. | F | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1337-1342 [PMID:9871762] |
| ChEMBL | In vitro inhibition of pig liver squalene epoxidase in HepG2 cells | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1337-1342 [PMID:9871762] |
| squalene monooxygenase/Squalene monooxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020] | ||||||||
| ChEMBL | In vitro inhibition of rat liver squalene epoxidase in HepG2 cells | B | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1337-1342 [PMID:9871762] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
