ketanserin [Ligand Id: 88] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL51 (Ketanserin, Ketanserin tartrate, KJK 945, NSC-758959, Perketan, R-41,468, R-41468, R 49945, R-49945, Serepress, Sufrexal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | - | - | - | Nature (1991) 350: 614-9 [PMID:1826762] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | In vitro binding affinity towards dDopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate | B | 5.52 | pKi | >3000 | nM | Ki | J Med Chem (1989) 32: 1431-1435 [PMID:2525621] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity for Dopamine receptor D2 by displacement of [3H]-spiperone | B | 6.62 | pKi | 240 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 509-512 [PMID:10743959] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand | B | 6.31 | pKi | 491 | nM | Ki | J Med Chem (1990) 33: 171-178 [PMID:2136916] |
| ChEMBL | Inhibitory constant against binding of [125I]- IBZM to rat striatal membrane | B | 6.44 | pKi | 359 | nM | Ki | J Med Chem (1988) 31: 1039-1043 [PMID:2966245] |
| ChEMBL | Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranes | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (1988) 31: 2247-2256 [PMID:2903929] |
| ChEMBL | Binding affinity at dopamine D2 receptor by [3H]spiperone displacement. | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (1994) 37: 950-962 [PMID:8151622] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Binding affinity towards human dopamine receptor D4 | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
| ChEMBL | Antagonist activity at histamine H1 receptor | F | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2012) 55: 5749-5759 [PMID:22694093] |
| Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389] | ||||||||
| ChEMBL | Antagonism against H1 histamine receptor of guinea pig ileum | F | 8.85 | pKd | 1.41 | nM | Kd | Bioorg Med Chem Lett (1995) 5: 667-672 |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Displacement of [125I]RTI-55 from human NET expressed in HEK293 cell membranes | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5HT1A receptor | B | 6.1 | pKd | 794.33 | nM | Kd | J Med Chem (2009) 52: 6107-6125 [PMID:19754201] |
| GtoPdb | - | - | 5 | pKi | - | - | - | Biochem J (1992) 285 ( Pt 3): 933-8 [PMID:1386736] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampus | B | 5.71 | pKi | 1933 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1229-1231 [PMID:11354383] |
| ChEMBL | Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand. | B | 5.72 | pKi | 1900 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue of rat brain | B | 5.74 | pKi | 1817 | nM | Ki | J Med Chem (1993) 36: 3161-3165 [PMID:8230102] |
| ChEMBL | Inhibitory concentration against binding of 5-hydroxytryptamine 1A receptor from striata of male Wistar rats by displacement of [3H]8-OH-DPAT | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 509-512 [PMID:10743959] |
| ChEMBL | The compound was evaluated for the ability to displace [3H]- 8-OH -DPAT from 5-hydroxytryptamine 1A receptor ( striata of male wistar rats) | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 2457-2461 [PMID:11078200] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
| ChEMBL | Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement. | B | 5.19 | pIC50 | 6500 | nM | IC50 | J Med Chem (1997) 40: 3497-3500 [PMID:9357514] |
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 328-34 [PMID:9303569]; Br J Pharmacol (1998) 123: 1655-65 [PMID:9605573] |
| 5-HT1B receptor in Mouse [GtoPdb: 2] [UniProtKB: P28334] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | - | - | - | Proc Natl Acad Sci USA (1992) 89: 3020-4 [PMID:1557407] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
| ChEMBL | Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. | B | 5.72 | pKi | 1900 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (1997) 356: 328-34 [PMID:9303569]; Mol Pharmacol (1996) 50: 1567-80 [PMID:8967979] |
| ChEMBL | Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | B | 6.57 | pIC50 | 270 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
| ChEMBL | Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement. | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (1997) 40: 3497-3500 [PMID:9357514] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Displacement of [125I]DOI from human 5HT2A receptor expressed in HEK293 cell membranes | B | 7.97 | pKi | 10.7 | nM | Ki | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| ChEMBL | Antagonist activity at 5HT2A receptor | F | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2012) 55: 5749-5759 [PMID:22694093] |
| ChEMBL | Displacement of radiolabeled ketanserin from human 5HT2A receptor | B | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Binding affinity to human 5-HT2A receptor by radioligand displacement assay | B | 9.31 | pKi | 0.49 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
| ChEMBL | Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter method | B | 9.35 | pKi | 0.45 | nM | Ki | Eur J Med Chem (2019) 176: 292-309 [PMID:31112891] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cells | B | 9.4 | pKi | 0.4 | nM | Ki | J Med Chem (2008) 51: 6808-6828 [PMID:18847250] |
| ChEMBL | Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK-293 cells | B | 9.52 | pKi | 0.3 | nM | Ki | Eur J Med Chem (2015) 92: 221-235 [PMID:25557493] |
| ChEMBL | Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEK293 cells | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
| ChEMBL | Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation counting | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (2017) 60: 349-361 [PMID:27997171] |
| ChEMBL | Displacement of [3H]ketanserin from human 5HT2A receptor | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (2011) 54: 5320-5334 [PMID:21726069] |
| ChEMBL | Displacement of [3H]ketanserein from 5HT2A receptor F340L mutant expressed in NIH3T3 cells | B | 9.64 | pKi | 0.23 | nM | Ki | J Med Chem (2008) 51: 6808-6828 [PMID:18847250] |
| GtoPdb | - | - | 9.7 | pKi | 0.2 | nM | Ki |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Life Sci (1996) 59: 1259-68 [PMID:8845011]; Life Sci (2003) 73: 193-207 [PMID:12738034] |
| ChEMBL | Antagonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay | F | 7.08 | pIC50 | 83.7 | nM | IC50 | J Med Chem (2018) 61: 10017-10039 [PMID:30383372] |
| ChEMBL | Antagonist activity at 5HT2A receptor (unknown origin) expressed in CHOK1 cells coexpressing Galpha15 assessed as inhibition of agonist-induced response incubated for 60 mins in incubator followed by 15 mins at room temperature by FLIPR assay | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2013) 56: 4671-4690 [PMID:23675993] |
| ChEMBL | Antagonist activity at human 5HT2A receptor expressed in EC80 serotonin-stimulated CHOK1 cells by calcium mobilization assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2530-2532 [PMID:19328689] |
| ChEMBL | Antagonist activity at human 5-HT2A receptor assessed as inhibition of 5-HT-mediated internal calcium mobilization by FLIPR assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 5102-5106 [PMID:26475518] |
| ChEMBL | Antagonist activity at human 5HT2A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay | F | 7.71 | pIC50 | 19.6 | nM | IC50 | Eur J Med Chem (2020) 207: 112709-112709 [PMID:32877805] |
| ChEMBL | Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation | F | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
| ChEMBL | Inhibition of human 5HT2A receptor | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2008) 51: 4150-4169 [PMID:18588282] |
| ChEMBL | Antagonist activity against human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as reduction in alpha-methylserotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method | F | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2015) 92: 221-235 [PMID:25557493] |
| ChEMBL | Inhibition of human 5-HT2A receptor | B | 8.59 | pIC50 | 2.6 | nM | IC50 | Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743] |
| ChEMBL | Displacement of radiolabeled ketanserin from human 5HT2A receptor | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Binding affinity to human 5-HT2A receptor by radioligand displacement assay | B | 9.05 | pIC50 | 0.9 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
| ChEMBL | Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter method | B | 9.09 | pIC50 | 0.82 | nM | IC50 | Eur J Med Chem (2019) 176: 292-309 [PMID:31112891] |
| ChEMBL | Binding affinity to human 5-HT2A receptor by radioligand displacement assay | B | 9.11 | pIC50 | 0.77 | nM | IC50 | Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449] |
| ChEMBL | Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation counting | B | 9.28 | pIC50 | 0.52 | nM | IC50 | J Med Chem (2017) 60: 349-361 [PMID:27997171] |
| ChEMBL | Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEK293 cells | B | 9.46 | pIC50 | 0.35 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
| ChEMBL | Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method | B | 9.46 | pIC50 | 0.35 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
| ChEMBL | Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay | F | 8.98 | pEC50 | 1.04 | nM | EC50 | Eur J Med Chem (2013) 63: 558-569 [PMID:23537943] |
| Serotonin 2a (5-HT2a) receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2490] [UniProtKB: P50129] | ||||||||
| ChEMBL | Antagonist activity at serotonin 5HT2A receptor assessed as effect on 5HT-induced isometric contractile force in isolated rings of pig coronary artery | F | 8.88 | pKd | 1.32 | nM | Kd | Bioorg Med Chem Lett (2008) 18: 3809-3813 [PMID:18534847] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Negative log concentration of antagonist on 5-hydroxytryptamine 2A receptor in rat thoracic aorta | F | 8.87 | pKd | 1.35 | nM | Kd | J Med Chem (2002) 45: 54-71 [PMID:11754579] |
| ChEMBL | Antagonism of 5-HT2A receptor of rat tail artery | F | 9.55 | pKd | 0.28 | nM | Kd | Bioorg Med Chem Lett (1995) 5: 667-672 |
| ChEMBL | Inhibitory constant on 5-hydroxytryptamine 2A receptor of Rat frontal cortex | B | 8.29 | pKi | 5.13 | nM | Ki | J Med Chem (2002) 45: 54-71 [PMID:11754579] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley cortex membrane | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2007) 50: 4214-4221 [PMID:17649988] |
| ChEMBL | Displacement of [3H]DOI-HCL from 5HT2A in Sprague-Dawley rat frontal cortex membranes measured after 20 mins | B | 8.62 | pKi | 2.4 | nM | Ki | J Med Chem (2017) 60: 2605-2628 [PMID:28244748] |
| ChEMBL | Displacement of [3H]- Ketanserin from rat cortex 5-hydroxytryptamine 2A receptor | B | 8.82 | pKi | 1.5 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1229-1231 [PMID:11354383] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat frontal cortex membranes measured after 20 mins | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2017) 60: 2605-2628 [PMID:28244748] |
| GtoPdb | - | - | 9 | pKi | - | - | - |
Mol Pharmacol (2000) 58: 877-86 [PMID:11040033]; J Pharmacol Exp Ther (1998) 286: 85-90 [PMID:9655845] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain cortex incubated for 15 mins | B | 9.07 | pKi | 0.85 | nM | Ki | Eur J Med Chem (2016) 116: 173-186 [PMID:27061981] |
| ChEMBL | Displacement of [3H]ketanserin from serotonin 5-HT2A receptor in Sprague-Dawley rat brain cortex homogenates incubated for 15 mins by liquid scintillation spectrometry | B | 9.07 | pKi | 0.85 | nM | Ki | Bioorg Med Chem (2017) 25: 5820-5837 [PMID:28943244] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat brain cortex by liquid scintillation counting | B | 9.07 | pKi | 0.85 | nM | Ki | Eur J Med Chem (2010) 45: 752-759 [PMID:19954866] |
| ChEMBL | Binding affinity to 5HT2A receptor in Sprague-Dawley rat frontal cortical homogenates after 15 mins | B | 9.07 | pKi | 0.85 | nM | Ki | Eur J Med Chem (2011) 46: 2206-2216 [PMID:21440338] |
| ChEMBL | Displacement of [3H]ketanserin from Sprague-Dawley rat brain cortex serotonin 5-HT2A receptor after 15 mins by liquid scintillation counting | B | 9.07 | pKi | 0.85 | nM | Ki | Eur J Med Chem (2012) 47: 520-529 [PMID:22133459] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain cortex incubated for 15 mins by liquid scintillation counting analysis | B | 9.07 | pKi | 0.85 | nM | Ki | Eur J Med Chem (2016) 110: 133-150 [PMID:26820556] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex membrane | B | 9.31 | pKi | 0.49 | nM | Ki | Bioorg Med Chem (2007) 15: 7581-7589 [PMID:17900912] |
| ChEMBL | Displacement of [3H]ketanserin from 5-HT2A receptor in Sprague-Dawley rat frontal cortex after 15 mins | B | 9.33 | pKi | 0.47 | nM | Ki | J Med Chem (2013) 56: 7851-7861 [PMID:24050112] |
| ChEMBL | Binding affinity towards rat 5-hydroxytryptamine 2A receptor was evaluated using [3H]- ketanserin as radioligand | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (1996) 39: 4928-4934 [PMID:8960552] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Life Sci (1996) 59: 1259-68 [PMID:8845011]; Life Sci (2003) 73: 193-207 [PMID:12738034]; Mol Pharmacol (1994) 46: 227-34 [PMID:8078486]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 17-24 [PMID:9459568] |
| ChEMBL | Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins | B | 6.74 | pKi | 180 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
| ChEMBL | Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins | B | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
| 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994] | ||||||||
| GtoPdb | - | - | 5.4 | pKi | - | - | - | Mol Pharmacol (1993) 43: 419-26 [PMID:8450835] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand. | B | 7 | pKi | 100 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| ChEMBL | Inhibitory constant was determined on 5-hydroxytryptamine 2C receptor of Bovine choroid plexus | B | 7.36 | pKi | 43.65 | nM | Ki | J Med Chem (2002) 45: 54-71 [PMID:11754579] |
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Life Sci (1996) 59: 1259-68 [PMID:8845011]; Life Sci (2003) 73: 193-207 [PMID:12738034]; J Neurochem (1999) 72: 2127-34 [PMID:10217294] |
| ChEMBL | Percent inhibition against 5-hydroxytryptamine 2C receptor at 1 uM | B | 8.57 | pIC50 | 2.7 | nM | IC50 | J Med Chem (2005) 48: 6887-6896 [PMID:16250647] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1C receptor in rat using [3H]mesulergine as radioligand | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (1992) 35: 4903-4910 [PMID:1479590] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 5A receptor | B | 4.7 | pKi | 20000 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 5A receptor was evaluated using [3H]-5-CT as radioligand | B | 4.7 | pKi | 20000 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| GtoPdb | - | - | 4.7 | pKi | - | - | - | FEBS Lett (1994) 355: 242-6 [PMID:7988681] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor | B | 5.87 | pKi | 1334 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| ChEMBL | Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells | B | 5.9 | pKi | 1258.93 | nM | Ki | Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003] |
| GtoPdb | - | - | 6.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 620-32 [PMID:11414657]; Br J Pharmacol (1997) 122: 126-32 [PMID:9298538]; J Biol Chem (1993) 268: 23422-6 [PMID:8226867]; Br J Pharmacol (1998) 124: 1300-6 [PMID:9720804] |
| 5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Mol Pharmacol (1993) 44: 229-36 [PMID:8394987] |
| 5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | - | - | - | J Biol Chem (1993) 268: 18200-4 [PMID:8394362] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cell membranes | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | The compound was tested for affinity towards sigma-3 receptor | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1994) 37: 4109-4117 [PMID:7990111] |
| Vesicular monoamine transporter 2/Synaptic vesicular amine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1893] [GtoPdb: 1012] [UniProtKB: Q05940] | ||||||||
| ChEMBL | Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method | B | 5.92 | pKi | 1190 | nM | Ki | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| GtoPdb | - | - | 6.3 | pKi | 540 | nM | Ki | Proc Natl Acad Sci USA (1996) 93: 5166-71 [PMID:8643547] |
| ChEMBL | Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method | B | 6.45 | pKi | 353 | nM | Ki | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| ChEMBL | Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting method | B | 7.11 | pKi | 77 | nM | Ki | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| ChEMBL | Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition and measured after 6 mins | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| Vesicular monoamine transporter 2/Synaptic vesicular amine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295886] [GtoPdb: 1012] [UniProtKB: Q8BRU6] | ||||||||
| ChEMBL | Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition and measured after 8 mins | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2018) 61: 9121-9131 [PMID:30240563] |
| Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666] | ||||||||
| ChEMBL | Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799] |
| α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| GtoPdb | - | - | 8.2 | pKi | - | - | - | Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121] |
| α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| GtoPdb | - | - | 8.2 | pKi | - | - | - | Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121] |
| α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
| GtoPdb | - | - | 7.8 | pKi | - | - | - | Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121] |
| D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
| GtoPdb | - | - | 5.6 | pKi | - | - | - | Nature (1991) 350: 614-9 [PMID:1826762] |
| Vesicular monoamine transporter 1 in Human [GtoPdb: 1011] [UniProtKB: P54219] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | 1700 | nM | Ki | Proc Natl Acad Sci USA (1996) 93: 5166-71 [PMID:8643547] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
