ChEMBL ligand: CHEMBL163 (A-84538, ABBOTT-84538, ABT-538, Empetus, Norvir, NSC-693184, Ritomune, Ritonavir, Ritonavir related compounds mixture, Ritonavirum, Ritovir, Viekirax, Viriton)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
CYP2C9/Cytochrome P450 2C9 in Human [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712] There should be some charts here, you may need to enable JavaScript!
CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] There should be some charts here, you may need to enable JavaScript!
CYP3A4/Cytochrome P450 3A4 in Human [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8] There should be some charts here, you may need to enable JavaScript!
MATE2/Multidrug and toxin extrusion protein 2 in Human [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum plasmepsin V/Plasmepsin V in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL3559649] [GtoPdb: 3106] [UniProtKB: Q8I6Z5] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii yoelii [ChEMBL: CHEMBL612328] There should be some charts here, you may need to enable JavaScript!
Protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] There should be some charts here, you may need to enable JavaScript!
V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] There should be some charts here, you may need to enable JavaScript!
CYP3A5 in Human [GtoPdb: 1338] [UniProtKB: P20815] There should be some charts here, you may need to enable JavaScript!
UDP glucuronosyltransferase family 1 member A1 in Human [GtoPdb: 2990] [UniProtKB: P22309] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	TP_TRANSPORTER: increase in mitoxantrone intracellular accumulation in BCRP-expressing HEK cells	F	4.71	pIC50	19500	nM	IC50	J Pharmacol Exp Ther (2004) 310: 334-341 [PMID:15007102]
CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712]
ChEMBL	DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	7.8	pIC50	16	nM	IC50	DrugMatrix in vitro pharmacology data
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL	DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	4.3	pIC50	50000	nM	IC50	DrugMatrix in vitro pharmacology data
CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684]
GtoPdb	-	-	7	pKi	<100	nM	Ki	Antimicrob Agents Chemother (2008) 52: 1663-9 [PMID:18285471]
ChEMBL	DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)	B	7.8	pIC50	16	nM	IC50	DrugMatrix in vitro pharmacology data
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Equilibrium constant for the interaction between inhibitor and HIV-1 Protease	B	9.22	pKd	0.61	nM	Kd	J Med Chem (2002) 45: 5430-5439 [PMID:12459011]
ChEMBL	Binding affinity for human immunodeficiency virus type 1 protease	B	9.22	pKd	0.6	nM	Kd	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Dissociation constant obtained by inhibition of mutant HIV-protease (A-44)	B	7.22	pKi	60	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Dissociation constant obtained by inhibition of mutant HIV-protease (K-60)	B	7.4	pKi	40	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Dissociation constant obtained by inhibition of mutant HIV-protease (V-18)	B	7.64	pKi	23	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Inhibitory concentration against HIV-1 protease	B	9.09	pKi	0.82	nM	Ki	J Med Chem (2001) 44: 3083-3091 [PMID:11543677]
ChEMBL	Inhibition constant for human immunodeficiency virus type 1 protease	B	9.23	pKi	0.59	nM	Ki	J Med Chem (2004) 47: 5953-5961 [PMID:15537350]
ChEMBL	Inhibition constant against HIV-1 Protease	B	9.23	pKi	0.59	nM	Ki	J Med Chem (2002) 45: 5430-5439 [PMID:12459011]
ChEMBL	Affinity against HIV protease	B	9.43	pKi	0.37	nM	Ki	J Med Chem (1997) 40: 4079-4088 [PMID:9406598]
ChEMBL	Binding affinity for HIV -1 Protease	B	9.43	pKi	0.37	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3217-3220 [PMID:10576691]
ChEMBL	Inhibitory activity against HIV-1 protease	B	9.43	pKi	0.37	nM	Ki	J Med Chem (1996) 39: 4299-4312 [PMID:8863807]
ChEMBL	Binding affinity to inhibit the purified wild-type HIV-1 Protease	B	9.43	pKi	0.37	nM	Ki	J Med Chem (1997) 40: 181-191 [PMID:9003516]
ChEMBL	Tested for inhibitor binding of D25N/V82A mutant of HIV PR	B	9.92	pKi	0.12	nM	Ki	J Med Chem (2004) 47: 2030-2036 [PMID:15056001]
ChEMBL	Dissociation constant obtained by inhibition of Wild-type protease	B	10.21	pKi	0.06	nM	Ki	J Med Chem (2000) 43: 3386-3399 [PMID:10978186]
ChEMBL	Inhibition of HIV protease	B	10.7	pKi	0.02	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1159-1162 [PMID:10866371]
ChEMBL	Inhibitory activity against purified HIV protease	B	10.7	pKi	0.02	nM	Ki	Bioorg Med Chem Lett (1995) 5: 2725-2728
ChEMBL	Inhibition constant of ritonavir towards HIV protease was determined	B	10.82	pKi	0.01	nM	Ki	Bioorg Med Chem Lett (1997) 7: 699-704
ChEMBL	Tested for inhibitor binding of wild-type HIV PR	B	10.82	pKi	0.01	nM	Ki	J Med Chem (2004) 47: 2030-2036 [PMID:15056001]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)	B	5.26	pKi	5462	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.86	pIC50	13655	nM	IC50	DrugMatrix in vitro pharmacology data
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	5.36	pIC50	4400	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
ChEMBL	Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
ChEMBL	Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis	B	7.1	pIC50	80	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
MATE2/Multidrug and toxin extrusion protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
ChEMBL	Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	4.63	pIC50	23700	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
ChEMBL	Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay	B	5.36	pIC50	4400	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.58	pKi	26606	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.18	pIC50	65542	nM	IC50	DrugMatrix in vitro pharmacology data
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	B	6.06	pKi	874	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	B	5.58	pIC50	2622	nM	IC50	DrugMatrix in vitro pharmacology data
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells	B	4.4	pIC50	39600	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3498-3504 [PMID:17664327]
ChEMBL	TP_TRANSPORTER: inhibition of cyclosporin A uptake (cyclosporin A: 10 uM) in MDR1-expressing LLC-PK1 cells	F	4.8	pIC50	15700	nM	IC50	J Pharmacol Exp Ther (2003) 304: 1161-1171 [PMID:12604693]
ChEMBL	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.92	pIC50	12000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells	F	4.92	pIC50	12000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells	F	5.42	pIC50	3800	nM	IC50	Drug Metab Dispos (2000) 28: 655-660 [PMID:10820137]
ChEMBL	Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC	F	5.82	pIC50	1500	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells	F	4.3	pIC50	50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium falciparum plasmepsin V/Plasmepsin V in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559649] [GtoPdb: 3106] [UniProtKB: Q8I6Z5]
ChEMBL	Inhibition of Plasmodium falciparum DC6 plasmepsin-5 using DABCYL-GNKRTLAQKQG-EDANS as substrate measured every 15 mins of 75 mins by fluorescence assay	B	4.7	pIC50	>20000	nM	IC50	ACS Med Chem Lett (2014) 5: 89-93 [PMID:24900778]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	4.79	pIC50	16230	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Antimicrobial activity against Plasmodium falciparum at ring stage	F	5.01	pIC50	9664	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antimalarial activity against Plasmodium falciparum FAC8	F	5.15	pEC50	7000	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring HFP-tagged Pfs16 protein after 48 hrs	F	5.3	pEC50	5000	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs	F	5.52	pEC50	3000	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs	F	5.52	pEC50	3000	nM	EC50	Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10	F	5.96	pEC50	1100	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2	F	6.07	pEC50	850	nM	EC50	Antimicrob Agents Chemother (2007) 51: 759-762 [PMID:17088482]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL	Antimicrobial activity against Plasmodium vivax at trophozoite stage	F	5.65	pIC50	2233	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328]
ChEMBL	Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs	F	7.47	pIC50	34.2	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1215-1220 [PMID:18212104]
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL	Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assay	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2010) 53: 607-615 [PMID:19961222]
ChEMBL	Inhibition of HIV1 protease using fluorogenic hexapeptide substrate (2-aminobenzoyl)Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg by fluorimeter	B	9.5	pKi	0.31	nM	Ki	Medchemcomm (2011) 2: 1093-1098
ChEMBL	Inhibition of HIV1 protease	B	10.01	pKi	0.1	nM	Ki	Bioorg Med Chem (2008) 16: 1299-1308 [PMID:17981045]
ChEMBL	Inhibition of HIV1 protease	B	10.47	pKi	0.03	nM	Ki	Antimicrob Agents Chemother (2007) 51: 4036-4043 [PMID:17638694]
ChEMBL	Inhibition of HIV1 protease	B	5.01	pIC50	9850	nM	IC50	Bioorg Med Chem (2013) 21: 1964-1971 [PMID:23415084]
ChEMBL	Inhibition of HIV-1 protease	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2014) 24: 989-994 [PMID:24411125]
ChEMBL	Inhibition of HIV1 3B protease infected in human MT4 cells assessed as protection from virus induced cytopathogenicity measured after 5 days post infection by MTT assay	B	6.82	pEC50	150	nM	EC50	Bioorg Med Chem Lett (2018) 28: 2379-2381 [PMID:29934245]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay	B	4.47	pIC50	33900	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay	B	4.61	pIC50	24800	nM	IC50	J Med Chem (2013) 56: 781-795 [PMID:23241029]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)	B	7.12	pIC50	76	nM	IC50	DrugMatrix in vitro pharmacology data
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL	DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)	B	5.3	pKi	4981	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr)	B	4.91	pIC50	12416	nM	IC50	DrugMatrix in vitro pharmacology data
CYP3A5 in Human [GtoPdb: 1338] [UniProtKB: P20815]
GtoPdb	-	-	6.92	pKi	120	nM	Ki	Curr Drug Metab (2005) 6: 413-54 [PMID:16248836]
UDP glucuronosyltransferase family 1 member A1 in Human [GtoPdb: 2990] [UniProtKB: P22309]
GtoPdb	-	-	5.77	pIC50	1700	nM	IC50	Drug Metab Dispos (2011) 39: 322-9 [PMID:21030469]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]