A1P [Ligand Id: 8806] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1099169 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arginase I/Arginase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089] | ||||||||
| ChEMBL | Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by surface plasmon resonance assay | B | 5.7 | pKd | 2000 | nM | Kd | J Med Chem (2010) 53: 4266-4276 [PMID:20441173] |
| GtoPdb | Dissociation constant measured using surface plasmon resonance assay. | - | 5.7 | pKd | 2000 | nM | Kd | J Med Chem (2010) 53: 4266-76 [PMID:20441173] |
| ChEMBL | Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay | B | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (2010) 53: 4266-4276 [PMID:20441173] |
| GtoPdb | Measured using an enzyme kinetics assay. | - | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (2010) 53: 4266-76 [PMID:20441173] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
