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ChEMBL ligand: CHEMBL180650 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-lipoxygenase activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4550] [UniProtKB: P20292] | ||||||||
ChEMBL | In vitro binding affinity against FLAP (5-Lipoxygenase activation protein) | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724] |
ChEMBL | Inhibition of FLAP | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2008) 51: 4059-4067 [PMID:18459759] |
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
ChEMBL | Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis | B | 6.02 | pIC50 | 960 | nM | IC50 | J Med Chem (2015) 58: 4727-4737 [PMID:25961169] |
ChEMBL | Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2015) 58: 4727-4737 [PMID:25961169] |
GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-5 [PMID:15953724] |
ChEMBL | Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assay | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2011) 54: 3163-3174 [PMID:21466167] |
mPGES2/Prostaglandin E synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7] | ||||||||
GtoPdb | - | - | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-5 [PMID:15953724] |
ChEMBL | In vitro inhibition against recombinant human mPGES-2 | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724] |
ChEMBL | Inhibition of human mPGES2 | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6816-6820 [PMID:18029174] |
ChEMBL | Inhibition of mPGES2 | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2008) 51: 4059-4067 [PMID:18459759] |
ChEMBL | Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1) | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724] |
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
ChEMBL | Inhibition of TX synthase | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2008) 51: 4059-4067 [PMID:18459759] |
ChEMBL | In vitro inhibition against human Thromboxane synthase | B | 6.02 | pIC50 | 950 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3352-3355 [PMID:15953724] |
ChEMBL | Inhibition of TX synthase | B | 6.02 | pIC50 | 950 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6816-6820 [PMID:18029174] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]